Fungal metabolism of 4-substituted amphetamines
1. rac.-4-Ethoxyamphetamine was incubated with 14 different yeast and fungal microorganisms. 4-Hydroxyamphetamine was the major metabolite; traces of N-acetyl-4-ethoxyamphetamine were also detected. 2. The major fungal (Cunninghamella) metabolite of 4-propoxyamphetamine and 4-benzyloxyamphetamine wa...
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| Veröffentlicht in: | Xenobiotica 1990, Vol.20 (6), p.583-590 |
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| container_issue | 6 |
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| container_title | Xenobiotica |
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| creator | Foster, B.C Nantais, L.M Wilson, D.L By, A.W Zamecnik, J Lodge, B.A |
| description | 1. rac.-4-Ethoxyamphetamine was incubated with 14 different yeast and fungal microorganisms. 4-Hydroxyamphetamine was the major metabolite; traces of N-acetyl-4-ethoxyamphetamine were also detected.
2. The major fungal (Cunninghamella) metabolite of 4-propoxyamphetamine and 4-benzyloxyamphetamine was 4-hydroxyamphetamine. The major metabolites of 4-methoxyamphetamine were N-acetyl-4-methoxyamphetamine and 4-hydroxyamphetamine.
3. Acetoin derivatives were formed when alkoxyamphetamine substrates were incubated in the presence of various fungi and yeasts.
4. The findings indicate that Cunninghamella echinulata may be a useful microbial model for drug disposition and interaction studies. |
| doi_str_mv | 10.3109/00498259009046873 |
| format | Article |
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2. The major fungal (Cunninghamella) metabolite of 4-propoxyamphetamine and 4-benzyloxyamphetamine was 4-hydroxyamphetamine. The major metabolites of 4-methoxyamphetamine were N-acetyl-4-methoxyamphetamine and 4-hydroxyamphetamine.
3. Acetoin derivatives were formed when alkoxyamphetamine substrates were incubated in the presence of various fungi and yeasts.
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2. The major fungal (Cunninghamella) metabolite of 4-propoxyamphetamine and 4-benzyloxyamphetamine was 4-hydroxyamphetamine. The major metabolites of 4-methoxyamphetamine were N-acetyl-4-methoxyamphetamine and 4-hydroxyamphetamine.
3. Acetoin derivatives were formed when alkoxyamphetamine substrates were incubated in the presence of various fungi and yeasts.
4. The findings indicate that Cunninghamella echinulata may be a useful microbial model for drug disposition and interaction studies.</description><subject>amphetamines</subject><subject>Amphetamines - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Gas</subject><subject>Cunninghamella</subject><subject>cunninghamella echinulata</subject><subject>Drug addictions</subject><subject>drug metabolism</subject><subject>Fungi - metabolism</subject><subject>interactions</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>metabolites</subject><subject>Molecular Structure</subject><subject>Toxicology</subject><subject>Yeasts - metabolism</subject><issn>0049-8254</issn><issn>1366-5928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKkvhA3BA7IXe0o49jv-IXlDVAlKlHkrP1iSxu6mceLEToX570u4CQkjl5MP7vTeeN4y95XCMHOwJgLRG1BbAglRG4zO24qhUVVthnrPVg14tgHzJXpVyBwCKC3HADoTg1ta4YicX83hLcT34iZoU-zKsU1jLqsxNmfppnny3pmG7WeShH315zV4EisW_2b-H7Obi_NvZl-ry6vPXs0-XVSuNmiqlERQhATQBNSdDpgElUCAYUMaTtp2XbROC1p3VHNtaQcdRdkRaWMBDdrTL3eb0ffZlckNfWh8jjT7NxZnHVbD-L8hrbUBKvYB8B7Y5lZJ9cNvcD5TvHQf30Kb7p83F824fPjeD73479vUt-oe9TqWlGDKNbV_-BFsUmiu5cKc7rh9DygP9SDl2bqL7mPIvEz71jY9_2Tee4rRpKXt3l-Y8Lod4con3O3eg5Og2L7NurgVwBK4lalXjT0_SqI4</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Foster, B.C</creator><creator>Nantais, L.M</creator><creator>Wilson, D.L</creator><creator>By, A.W</creator><creator>Zamecnik, J</creator><creator>Lodge, B.A</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Fungal metabolism of 4-substituted amphetamines</title><author>Foster, B.C ; Nantais, L.M ; Wilson, D.L ; By, A.W ; Zamecnik, J ; Lodge, B.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-67306a3a00bf371a8a8b06232308068ea79de4cbff77d9713c560d134daa72903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>amphetamines</topic><topic>Amphetamines - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Gas</topic><topic>Cunninghamella</topic><topic>cunninghamella echinulata</topic><topic>Drug addictions</topic><topic>drug metabolism</topic><topic>Fungi - metabolism</topic><topic>interactions</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>metabolites</topic><topic>Molecular Structure</topic><topic>Toxicology</topic><topic>Yeasts - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foster, B.C</creatorcontrib><creatorcontrib>Nantais, L.M</creatorcontrib><creatorcontrib>Wilson, D.L</creatorcontrib><creatorcontrib>By, A.W</creatorcontrib><creatorcontrib>Zamecnik, J</creatorcontrib><creatorcontrib>Lodge, B.A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Xenobiotica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foster, B.C</au><au>Nantais, L.M</au><au>Wilson, D.L</au><au>By, A.W</au><au>Zamecnik, J</au><au>Lodge, B.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fungal metabolism of 4-substituted amphetamines</atitle><jtitle>Xenobiotica</jtitle><addtitle>Xenobiotica</addtitle><date>1990</date><risdate>1990</risdate><volume>20</volume><issue>6</issue><spage>583</spage><epage>590</epage><pages>583-590</pages><issn>0049-8254</issn><eissn>1366-5928</eissn><coden>XENOBH</coden><abstract>1. rac.-4-Ethoxyamphetamine was incubated with 14 different yeast and fungal microorganisms. 4-Hydroxyamphetamine was the major metabolite; traces of N-acetyl-4-ethoxyamphetamine were also detected.
2. The major fungal (Cunninghamella) metabolite of 4-propoxyamphetamine and 4-benzyloxyamphetamine was 4-hydroxyamphetamine. The major metabolites of 4-methoxyamphetamine were N-acetyl-4-methoxyamphetamine and 4-hydroxyamphetamine.
3. Acetoin derivatives were formed when alkoxyamphetamine substrates were incubated in the presence of various fungi and yeasts.
4. The findings indicate that Cunninghamella echinulata may be a useful microbial model for drug disposition and interaction studies.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>2219953</pmid><doi>10.3109/00498259009046873</doi><tpages>8</tpages></addata></record> |
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| ispartof | Xenobiotica, 1990, Vol.20 (6), p.583-590 |
| issn | 0049-8254 1366-5928 |
| language | eng |
| recordid | cdi_pubmed_primary_2219953 |
| source | MEDLINE; Taylor & Francis; Taylor & Francis Medical Library - CRKN |
| subjects | amphetamines Amphetamines - metabolism Biological and medical sciences Chromatography, Gas Cunninghamella cunninghamella echinulata Drug addictions drug metabolism Fungi - metabolism interactions Mass Spectrometry Medical sciences metabolites Molecular Structure Toxicology Yeasts - metabolism |
| title | Fungal metabolism of 4-substituted amphetamines |
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