Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate
In contrast to the Pt( iv ) derivatives of cisplatin, Pt( iv ) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (6), p.847-849 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 48 |
| creator | Zhang, Jenny Z Wexselblatt, Ezequiel Hambley, Trevor W Gibson, Dan |
| description | In contrast to the Pt(
iv
) derivatives of cisplatin, Pt(
iv
) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.
Pt(
iv
) analogs of oxaliplatin with axial hydroxido ligands are reduced more rapidly than complexes with axial acetato ligands. |
| doi_str_mv | 10.1039/c1cc16647f |
| format | Article |
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iv
) derivatives of cisplatin, Pt(
iv
) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.
Pt(
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iv
) derivatives of cisplatin, Pt(
iv
) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.
Pt(
iv
) analogs of oxaliplatin with axial hydroxido ligands are reduced more rapidly than complexes with axial acetato ligands.</description><subject>Amines</subject><subject>Analogs</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Ascorbic Acid - chemistry</subject><subject>Correlation</subject><subject>Derivatives</subject><subject>Electrochemistry</subject><subject>Electrode potentials</subject><subject>Ligands</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Organoplatinum Compounds - chemistry</subject><subject>Oxidation-Reduction</subject><subject>Prodrugs - chemistry</subject><subject>Reducing agents</subject><subject>Reduction</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9PFTEUxRsiEQQ37DVlJZIM9O_MdGkmoiQkuoCE3aTT3sqYvunY9gl8Ez6uHR7CjnbRm3N-OTfNQeiAkhNKuDo11Bha16JxW2iX8lpUUrTXb5ZZqqrhQu6gdyn9JuVQ2b5FO4xRJrhku-jhZz4a_37GetI-_Eo4OBzutB9nr_M44XyjM7YBTyFjF7wPt0UCDHczmAwWmxAjLGiY8AD5FmDC4IsXg7mB1Wi0xxHs2jwSc8gw5bFoerI46gzLvhd_uMc6lcihOPto22mf4P3Tu4euzr5edt-rix_fzrsvF5XhdZMr1hKiy-V8cJIrkIMeakukUNC01lmmCDON1spIaqV1DVBbS1ZTJ4UTreN76NMmd47hzxpS7ldjMuC9niCsU68oVUISqgp59CpJWcsbwohqCnq8QU0MKUVw_RzHlY73PSX90lnf0a577OyswB-fctfDCuwz-r-kAhxugJjMs_tSej_b5RsfXmP4P1hLqd4</recordid><startdate>20120121</startdate><enddate>20120121</enddate><creator>Zhang, Jenny Z</creator><creator>Wexselblatt, Ezequiel</creator><creator>Hambley, Trevor W</creator><creator>Gibson, Dan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20120121</creationdate><title>Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate</title><author>Zhang, Jenny Z ; Wexselblatt, Ezequiel ; Hambley, Trevor W ; Gibson, Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-2800a0a033bf539e5bab6d0549e78dfd2902c7aa9c51d5df7e1d65261f54f48f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amines</topic><topic>Analogs</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Ascorbic Acid - chemistry</topic><topic>Correlation</topic><topic>Derivatives</topic><topic>Electrochemistry</topic><topic>Electrode potentials</topic><topic>Ligands</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Organoplatinum Compounds - chemistry</topic><topic>Oxidation-Reduction</topic><topic>Prodrugs - chemistry</topic><topic>Reducing agents</topic><topic>Reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jenny Z</creatorcontrib><creatorcontrib>Wexselblatt, Ezequiel</creatorcontrib><creatorcontrib>Hambley, Trevor W</creatorcontrib><creatorcontrib>Gibson, Dan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jenny Z</au><au>Wexselblatt, Ezequiel</au><au>Hambley, Trevor W</au><au>Gibson, Dan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2012-01-21</date><risdate>2012</risdate><volume>48</volume><issue>6</issue><spage>847</spage><epage>849</epage><pages>847-849</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>In contrast to the Pt(
iv
) derivatives of cisplatin, Pt(
iv
) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.
Pt(
iv
) analogs of oxaliplatin with axial hydroxido ligands are reduced more rapidly than complexes with axial acetato ligands.</abstract><cop>England</cop><pmid>22124352</pmid><doi>10.1039/c1cc16647f</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2012-01, Vol.48 (6), p.847-849 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_pubmed_primary_22124352 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amines Analogs Antineoplastic Agents - chemistry Ascorbic Acid - chemistry Correlation Derivatives Electrochemistry Electrode potentials Ligands Magnetic Resonance Spectroscopy Organoplatinum Compounds - chemistry Oxidation-Reduction Prodrugs - chemistry Reducing agents Reduction |
| title | Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate |
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