Effect of vehicle systems, pH and enhancers on the permeation of highly lipophilic aripiprazole from Carbopol 971P gel systems across human cadaver skin

The objective of this study was to investigate the effect of vehicle systems, pH and enhancers on the permeation of a highly lipophilic basic drug aripiprazole (ARPZ) through human cadaver skin. Solubility of ARPZ in single, binary, tertiary, and quaternary vehicle systems of N-methyl pyrrolidone (N...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug development and industrial pharmacy 2012-03, Vol.38 (3), p.323-330
Hauptverfasser:	Hossain, Muhammed Anwar, Ahmed, Salah U., Plakogiannis, Fotios M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - chemistry Administration, Cutaneous Antipsychotic Agents - chemistry Antipsychotic Agents - pharmacokinetics Aripiprazole dimethyl sulfoxide Drug Delivery Systems fatty acids Fatty Acids - metabolism Gels - pharmacology Humans Hydrogen-Ion Concentration isopropyl myristate N-methyl pyrrolidone penetration enhancer Permeability Pharmaceutical Vehicles - pharmacology Piperazines - chemistry Piperazines - pharmacokinetics Psychotropic drug quaternary vehicle systems Quinolones - chemistry Quinolones - pharmacokinetics Skin - metabolism Skin Absorption stratum corneum transdermal delivery system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!