Clinical, Diagnostic and Therapeutic Approaches to Complications of Brucellosis: An Experience of 12 Years
Objective: To describe the clinical presentations, laboratory findings, prevalence and pattern of complications and the response to treatment of brucellosis in a 12-year period in a Turkish research hospital. Materials and Methods: Between 1996 and 2008, 231 patients were diagnosed with brucellosis...
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| Veröffentlicht in: | Medical principles and practice 2012, Vol.21 (1), p.46-50 |
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| creator | Mermut, Gülşen Özgenç, Onur Avcı, Meltem Olut, Ali Ilgın Öktem, Ebru Genç, Vecdi Evren Arı, Alpay Coskuner, Seher Ayten |
| description | Objective: To describe the clinical presentations, laboratory findings, prevalence and pattern of complications and the response to treatment of brucellosis in a 12-year period in a Turkish research hospital. Materials and Methods: Between 1996 and 2008, 231 patients were diagnosed with brucellosis and treated in our clinic. Medical records of 189 of the 231 patients with at least one demonstrable complication of the disease were reviewed for anamnesis, diagnosis, complications, treatment and clinical outcomes. Results: The decreasing order of the complications was: hematological, 104 (55%); osteoarticular, 70 (37%); hepatobiliary, 59 (31%), and gastrointestinal, 23 (12%). The most common laboratory findings were anemia, lymphomonocytosis, elevated sedimentation rate and C-reactive protein, and elevated aminotransaminases. Conclusion: The hematological, osteoarticular and hepatobiliary manifestations were predominant. Bursitis, synovitis, glomerulonephritis, cutaneous lesion and deep vein thrombosis were the rare complications observed in our study. In clinical practice, brucellosis should be considered in the differential diagnosis in the presence of infrequent complications. |
| doi_str_mv | 10.1159/000331588 |
| format | Article |
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Materials and Methods: Between 1996 and 2008, 231 patients were diagnosed with brucellosis and treated in our clinic. Medical records of 189 of the 231 patients with at least one demonstrable complication of the disease were reviewed for anamnesis, diagnosis, complications, treatment and clinical outcomes. Results: The decreasing order of the complications was: hematological, 104 (55%); osteoarticular, 70 (37%); hepatobiliary, 59 (31%), and gastrointestinal, 23 (12%). The most common laboratory findings were anemia, lymphomonocytosis, elevated sedimentation rate and C-reactive protein, and elevated aminotransaminases. Conclusion: The hematological, osteoarticular and hepatobiliary manifestations were predominant. Bursitis, synovitis, glomerulonephritis, cutaneous lesion and deep vein thrombosis were the rare complications observed in our study. In clinical practice, brucellosis should be considered in the differential diagnosis in the presence of infrequent complications.</description><identifier>ISSN: 1011-7571</identifier><identifier>EISSN: 1423-0151</identifier><identifier>DOI: 10.1159/000331588</identifier><identifier>PMID: 22024559</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adolescent ; Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; Blood Sedimentation ; Brucellosis - complications ; Brucellosis - diagnosis ; Brucellosis - drug therapy ; C-Reactive Protein - metabolism ; Diagnosis, Differential ; Doxycycline - therapeutic use ; Female ; Gastrointestinal Diseases - diagnosis ; Gastrointestinal Diseases - drug therapy ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - microbiology ; Hematologic Diseases - diagnosis ; Hematologic Diseases - drug therapy ; Hematologic Diseases - epidemiology ; Hematologic Diseases - microbiology ; Humans ; Joint Diseases - diagnosis ; Joint Diseases - drug therapy ; Joint Diseases - epidemiology ; Joint Diseases - microbiology ; Male ; Middle Aged ; Original Paper ; Prevalence ; Retrospective Studies ; Rifampin - therapeutic use ; Streptomycin - therapeutic use ; Time Factors ; Turkey ; Young Adult</subject><ispartof>Medical principles and practice, 2012, Vol.21 (1), p.46-50</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-4192cf215c42e363f6a732a6d3f3c79398a252eaa1f6d74dd29b1e507b9a1ba83</citedby><cites>FETCH-LOGICAL-c340t-4192cf215c42e363f6a732a6d3f3c79398a252eaa1f6d74dd29b1e507b9a1ba83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22024559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mermut, Gülşen</creatorcontrib><creatorcontrib>Özgenç, Onur</creatorcontrib><creatorcontrib>Avcı, Meltem</creatorcontrib><creatorcontrib>Olut, Ali Ilgın</creatorcontrib><creatorcontrib>Öktem, Ebru</creatorcontrib><creatorcontrib>Genç, Vecdi Evren</creatorcontrib><creatorcontrib>Arı, Alpay</creatorcontrib><creatorcontrib>Coskuner, Seher Ayten</creatorcontrib><title>Clinical, Diagnostic and Therapeutic Approaches to Complications of Brucellosis: An Experience of 12 Years</title><title>Medical principles and practice</title><addtitle>Med Princ Pract</addtitle><description>Objective: To describe the clinical presentations, laboratory findings, prevalence and pattern of complications and the response to treatment of brucellosis in a 12-year period in a Turkish research hospital. Materials and Methods: Between 1996 and 2008, 231 patients were diagnosed with brucellosis and treated in our clinic. Medical records of 189 of the 231 patients with at least one demonstrable complication of the disease were reviewed for anamnesis, diagnosis, complications, treatment and clinical outcomes. Results: The decreasing order of the complications was: hematological, 104 (55%); osteoarticular, 70 (37%); hepatobiliary, 59 (31%), and gastrointestinal, 23 (12%). The most common laboratory findings were anemia, lymphomonocytosis, elevated sedimentation rate and C-reactive protein, and elevated aminotransaminases. Conclusion: The hematological, osteoarticular and hepatobiliary manifestations were predominant. Bursitis, synovitis, glomerulonephritis, cutaneous lesion and deep vein thrombosis were the rare complications observed in our study. In clinical practice, brucellosis should be considered in the differential diagnosis in the presence of infrequent complications.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Blood Sedimentation</subject><subject>Brucellosis - complications</subject><subject>Brucellosis - diagnosis</subject><subject>Brucellosis - drug therapy</subject><subject>C-Reactive Protein - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Doxycycline - therapeutic use</subject><subject>Female</subject><subject>Gastrointestinal Diseases - diagnosis</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>Gastrointestinal Diseases - epidemiology</subject><subject>Gastrointestinal Diseases - microbiology</subject><subject>Hematologic Diseases - diagnosis</subject><subject>Hematologic Diseases - drug therapy</subject><subject>Hematologic Diseases - epidemiology</subject><subject>Hematologic Diseases - microbiology</subject><subject>Humans</subject><subject>Joint Diseases - diagnosis</subject><subject>Joint Diseases - drug therapy</subject><subject>Joint Diseases - epidemiology</subject><subject>Joint Diseases - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Rifampin - therapeutic use</subject><subject>Streptomycin - therapeutic use</subject><subject>Time Factors</subject><subject>Turkey</subject><subject>Young Adult</subject><issn>1011-7571</issn><issn>1423-0151</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPwzAQhC0E4lE4cEfIN4REwGvHTcKtlKeExKUcOEVbZ1Nc0jjYiQT_nkQtPe2u9pvRaBg7BXENoLMbIYRSoNN0hx1CLFUkQMNuvwuAKNEJHLCjEJY9liol9tmBlELGWmeHbDmtbG0NVlf83uKidqG1hmNd8NkneWyoG-5J03iH5pMCbx2fulVT9ZrWujpwV_I73xmqKhdsuOWTmj_8NOQt1YaGL0j-QejDMdsrsQp0spkj9v74MJs-R69vTy_TyWtkVCzaKIZMmlKCNrEkNVblGBMlcVyoUpkkU1mKUktChHJcJHFRyGwOpEUyzxDmmKoRu1j79pm_OwptvrJhyIc1uS7kmUj7XmIYyMs1abwLwVOZN96u0P_mIPKh2XzbbM-eb1y7-YqKLflfZQ-crYEv9AvyW2Cj_wPwNHuO</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Mermut, Gülşen</creator><creator>Özgenç, Onur</creator><creator>Avcı, Meltem</creator><creator>Olut, Ali Ilgın</creator><creator>Öktem, Ebru</creator><creator>Genç, Vecdi Evren</creator><creator>Arı, Alpay</creator><creator>Coskuner, Seher Ayten</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Clinical, Diagnostic and Therapeutic Approaches to Complications of Brucellosis: An Experience of 12 Years</title><author>Mermut, Gülşen ; 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Materials and Methods: Between 1996 and 2008, 231 patients were diagnosed with brucellosis and treated in our clinic. Medical records of 189 of the 231 patients with at least one demonstrable complication of the disease were reviewed for anamnesis, diagnosis, complications, treatment and clinical outcomes. Results: The decreasing order of the complications was: hematological, 104 (55%); osteoarticular, 70 (37%); hepatobiliary, 59 (31%), and gastrointestinal, 23 (12%). The most common laboratory findings were anemia, lymphomonocytosis, elevated sedimentation rate and C-reactive protein, and elevated aminotransaminases. Conclusion: The hematological, osteoarticular and hepatobiliary manifestations were predominant. Bursitis, synovitis, glomerulonephritis, cutaneous lesion and deep vein thrombosis were the rare complications observed in our study. In clinical practice, brucellosis should be considered in the differential diagnosis in the presence of infrequent complications.</abstract><cop>Basel, Switzerland</cop><pmid>22024559</pmid><doi>10.1159/000331588</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Anti-Bacterial Agents - therapeutic use Blood Sedimentation Brucellosis - complications Brucellosis - diagnosis Brucellosis - drug therapy C-Reactive Protein - metabolism Diagnosis, Differential Doxycycline - therapeutic use Female Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - epidemiology Gastrointestinal Diseases - microbiology Hematologic Diseases - diagnosis Hematologic Diseases - drug therapy Hematologic Diseases - epidemiology Hematologic Diseases - microbiology Humans Joint Diseases - diagnosis Joint Diseases - drug therapy Joint Diseases - epidemiology Joint Diseases - microbiology Male Middle Aged Original Paper Prevalence Retrospective Studies Rifampin - therapeutic use Streptomycin - therapeutic use Time Factors Turkey Young Adult |
| title | Clinical, Diagnostic and Therapeutic Approaches to Complications of Brucellosis: An Experience of 12 Years |
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