Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system

There is increasing concern that some anticoagulants can paradoxically increase thrombogenesis under certain circumstances. Previously, we demonstrated that at certain doses a direct thrombin inhibitor, melagatran, worsens the coagulation status induced by tissue factor (TF) injection in a rat model...

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Veröffentlicht in:	Thrombosis and haemostasis 2011-12, Vol.106 (6), p.1076-1083
Hauptverfasser:	Furugohri, Taketoshi, Sugiyama, Nobutoshi, Morishima, Yoshiyuki, Shibano, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - pharmacology Antithrombins - pharmacology Biological and medical sciences Blood Coagulation - drug effects Blood Coagulation Tests Blood Coagulation, Fibrinolysis and Cellular Haemostasis Blood coagulation. Blood cells Enzyme Activation - drug effects Factor Xa - biosynthesis Factor Xa - pharmacology Factor Xa inhibitor Feedback, Physiological Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Heparin - pharmacology Humans Medical sciences Molecular and cellular biology negative-feedback system Platelet diseases and coagulopathies Protein C Protein C - metabolism Pyridines - pharmacology Thiazoles - pharmacology Thrombin - analysis Thrombin - biosynthesis thrombin inhibitor thrombomodulin Thrombomodulin - metabolism
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