Validation of a Research Case Definition of Gulf War Illness in the 1991 US Military Population
Background: A case definition of Gulf War illness with 3 primary variants, previously developed by factor analysis of symptoms in a US Navy construction battalion and validated in clinic veterans, identified ill veterans with objective abnormalities of brain function. This study tests prestated hypo...
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| Veröffentlicht in: | Neuroepidemiology 2011-10, Vol.37 (2), p.129-140 |
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| creator | Iannacchione, Vincent G. Dever, Jill A. Bann, Carla M. Considine, Kathleen A. Creel, Darryl Carson, Christopher P. Best, Heather Haley, Robert W. |
| description | Background: A case definition of Gulf War illness with 3 primary variants, previously developed by factor analysis of symptoms in a US Navy construction battalion and validated in clinic veterans, identified ill veterans with objective abnormalities of brain function. This study tests prestated hypotheses of its external validity. Methods: A stratified probability sample (n = 8,020), selected from a sampling frame of the 3.5 million Gulf War era US military veterans, completed a computer-assisted telephone interview survey. Application of the prior factor weights to the subjects’ responses generated the case definition. Results: The structural equation model of the case definition fit both random halves of the population sample well (root mean-square error of approximation = 0.015). The overall case definition was 3.87 times (95% confidence interval, 2.61–5.74) more prevalent in the deployed than the deployable nondeployed veterans: 3.33 (1.10–10.10) for syndrome variant 1; 5.11 (2.43–10.75) for variant 2, and 4.25 (2.33–7.74) for variant 3. Functional status on SF-12 was greatly reduced (effect sizes, 1.0–2.0) in veterans meeting the overall and variant case definitions. Conclusions: The factor case definition applies to the full Gulf War veteran population and has good characteristics for research. |
| doi_str_mv | 10.1159/000331478 |
| format | Article |
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This study tests prestated hypotheses of its external validity. Methods: A stratified probability sample (n = 8,020), selected from a sampling frame of the 3.5 million Gulf War era US military veterans, completed a computer-assisted telephone interview survey. Application of the prior factor weights to the subjects’ responses generated the case definition. Results: The structural equation model of the case definition fit both random halves of the population sample well (root mean-square error of approximation = 0.015). The overall case definition was 3.87 times (95% confidence interval, 2.61–5.74) more prevalent in the deployed than the deployable nondeployed veterans: 3.33 (1.10–10.10) for syndrome variant 1; 5.11 (2.43–10.75) for variant 2, and 4.25 (2.33–7.74) for variant 3. Functional status on SF-12 was greatly reduced (effect sizes, 1.0–2.0) in veterans meeting the overall and variant case definitions. Conclusions: The factor case definition applies to the full Gulf War veteran population and has good characteristics for research.</description><identifier>ISSN: 0251-5350</identifier><identifier>EISSN: 1423-0208</identifier><identifier>DOI: 10.1159/000331478</identifier><identifier>PMID: 21986258</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Brain ; Factor analysis ; Female ; Gulf War ; Humans ; Male ; Mathematical models ; Methods in Neuroepidemiology ; Middle Aged ; Military personnel ; Models, Statistical ; Navy ; Persian Gulf Syndrome - diagnosis ; Persian Gulf Syndrome - epidemiology ; Population Surveillance - methods ; Random Allocation ; Sampling ; Surveys and Questionnaires - standards ; United States - epidemiology ; Veterans</subject><ispartof>Neuroepidemiology, 2011-10, Vol.37 (2), p.129-140</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-36bda286e5e9cbed7234582098b86e2e5485a7e118d36de7be6826d6a3b81bb3</citedby><cites>FETCH-LOGICAL-c399t-36bda286e5e9cbed7234582098b86e2e5485a7e118d36de7be6826d6a3b81bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21986258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iannacchione, Vincent G.</creatorcontrib><creatorcontrib>Dever, Jill A.</creatorcontrib><creatorcontrib>Bann, Carla M.</creatorcontrib><creatorcontrib>Considine, Kathleen A.</creatorcontrib><creatorcontrib>Creel, Darryl</creatorcontrib><creatorcontrib>Carson, Christopher P.</creatorcontrib><creatorcontrib>Best, Heather</creatorcontrib><creatorcontrib>Haley, Robert W.</creatorcontrib><title>Validation of a Research Case Definition of Gulf War Illness in the 1991 US Military Population</title><title>Neuroepidemiology</title><addtitle>Neuroepidemiology</addtitle><description>Background: A case definition of Gulf War illness with 3 primary variants, previously developed by factor analysis of symptoms in a US Navy construction battalion and validated in clinic veterans, identified ill veterans with objective abnormalities of brain function. This study tests prestated hypotheses of its external validity. Methods: A stratified probability sample (n = 8,020), selected from a sampling frame of the 3.5 million Gulf War era US military veterans, completed a computer-assisted telephone interview survey. Application of the prior factor weights to the subjects’ responses generated the case definition. Results: The structural equation model of the case definition fit both random halves of the population sample well (root mean-square error of approximation = 0.015). The overall case definition was 3.87 times (95% confidence interval, 2.61–5.74) more prevalent in the deployed than the deployable nondeployed veterans: 3.33 (1.10–10.10) for syndrome variant 1; 5.11 (2.43–10.75) for variant 2, and 4.25 (2.33–7.74) for variant 3. Functional status on SF-12 was greatly reduced (effect sizes, 1.0–2.0) in veterans meeting the overall and variant case definitions. Conclusions: The factor case definition applies to the full Gulf War veteran population and has good characteristics for research.</description><subject>Brain</subject><subject>Factor analysis</subject><subject>Female</subject><subject>Gulf War</subject><subject>Humans</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Methods in Neuroepidemiology</subject><subject>Middle Aged</subject><subject>Military personnel</subject><subject>Models, Statistical</subject><subject>Navy</subject><subject>Persian Gulf Syndrome - diagnosis</subject><subject>Persian Gulf Syndrome - epidemiology</subject><subject>Population Surveillance - methods</subject><subject>Random Allocation</subject><subject>Sampling</subject><subject>Surveys and Questionnaires - standards</subject><subject>United States - epidemiology</subject><subject>Veterans</subject><issn>0251-5350</issn><issn>1423-0208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0cFPFDEUBvCGaGBZOXg3pPFCPAy-10677ZEsiCQQjSIeJ52ZN1LozqztzIH_3uoue-DiqUn765e-foy9RThFVPYjAEiJ5cLssRmWQhYgwLxiMxAKCyUVHLDDlB4AMjZ2nx0ItEYLZWasunPBt270Q8-Hjjv-jRK52NzzpUvEz6nzvX8-vZxCx3-6yK9C6Ckl7ns-3hNHa5H_-M5vfPCji0_867Cewr_QN-x150Kio-06Z7efLm6Xn4vrL5dXy7PropHWjoXUdeuE0aTINjW1CyFLZQRYU-dNQao0yi0I0bRSt7SoSRuhW-1kbbCu5ZydbGLXcfg9URqrlU8NheB6GqZUWUTUKMH8XwLoEkqELN-_kA_DFPs8RY4rUZc6v3LOPmxQE4eUInXVOvpV_oMKofpbTrUrJ9vjbeBUr6jdyec2Mni3AY8u_qK4A9v7fwBut49u</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Iannacchione, Vincent G.</creator><creator>Dever, Jill A.</creator><creator>Bann, Carla M.</creator><creator>Considine, Kathleen A.</creator><creator>Creel, Darryl</creator><creator>Carson, Christopher P.</creator><creator>Best, Heather</creator><creator>Haley, Robert W.</creator><general>S. 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This study tests prestated hypotheses of its external validity. Methods: A stratified probability sample (n = 8,020), selected from a sampling frame of the 3.5 million Gulf War era US military veterans, completed a computer-assisted telephone interview survey. Application of the prior factor weights to the subjects’ responses generated the case definition. Results: The structural equation model of the case definition fit both random halves of the population sample well (root mean-square error of approximation = 0.015). The overall case definition was 3.87 times (95% confidence interval, 2.61–5.74) more prevalent in the deployed than the deployable nondeployed veterans: 3.33 (1.10–10.10) for syndrome variant 1; 5.11 (2.43–10.75) for variant 2, and 4.25 (2.33–7.74) for variant 3. Functional status on SF-12 was greatly reduced (effect sizes, 1.0–2.0) in veterans meeting the overall and variant case definitions. Conclusions: The factor case definition applies to the full Gulf War veteran population and has good characteristics for research.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21986258</pmid><doi>10.1159/000331478</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Brain Factor analysis Female Gulf War Humans Male Mathematical models Methods in Neuroepidemiology Middle Aged Military personnel Models, Statistical Navy Persian Gulf Syndrome - diagnosis Persian Gulf Syndrome - epidemiology Population Surveillance - methods Random Allocation Sampling Surveys and Questionnaires - standards United States - epidemiology Veterans |
| title | Validation of a Research Case Definition of Gulf War Illness in the 1991 US Military Population |
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