Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis

The diheme enzyme MauG catalyzes the posttranslational modification of the precursor protein of methylamine dehydrogenase (preMADH) to complete biosynthesis of its protein-derived tryptophan tryptophylquinone (TTQ) cofactor. Catalysis proceeds through a high valent bis-Fe(IV) redox state and require...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (41), p.16956-16961
Hauptverfasser:	Tarboush, Nafez Abu, Jensen, Lyndal M. R, Yukl, Erik T, Geng, Jiafeng, Liu, Aimin, Wilmot, Carrie M, Davidson, Victor L
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Amino Acid Substitution Amino acids Atoms Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism BASIC BIOLOGICAL SCIENCES BENZOQUINONES Biochemistry Biological Sciences BIOSYNTHESIS CATALYSIS catalytic activity CRYSTAL STRUCTURE Crystallography, X-Ray Dehydrogenases ELECTRON TRANSFER Electron tunneling Enzyme Precursors - chemistry Enzyme Precursors - metabolism ENZYMES HEME heme iron Hydroquinones Indolequinones - biosynthesis IRON Kinetics METHYLAMINE Models, Molecular MODIFICATIONS Multienzyme Complexes - chemistry Multienzyme Complexes - genetics Multienzyme Complexes - metabolism MUTAGENESIS Mutagenesis, Site-Directed Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism MUTATIONS OXIDATION Oxidation-Reduction OXIDOREDUCTASES Oxidoreductases Acting on CH-NH Group Donors - chemistry Oxidoreductases Acting on CH-NH Group Donors - metabolism Paracoccus denitrificans - enzymology Paracoccus denitrificans - genetics post-translational modification PRECURSOR Protein Processing, Post-Translational protein structure PROTEINS Quinones Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism RESIDUES Spectrophotometry TRYPTOPHAN Tryptophan - analogs & derivatives Tryptophan - biosynthesis Tryptophan - chemistry Tryptophan - genetics
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