Collectrin and ACE2 in renal and intestinal amino acid transport
Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this review we present the results concerning the dependence of their apical expression with their association to partner pro...
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| Veröffentlicht in: | Channels (Austin, Tex.) Tex.), 2011-09, Vol.5 (5), p.410-423 |
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| creator | Singer, Dustin Camargo, Simone M.R. |
| description | Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this review we present the results concerning the dependence of their apical expression with their association to partner proteins. We will in particular focus on the situation of B0AT1 and B0AT3, that associate with members of the renin-angiotensin system (RAS), namely Tmem27 and angiotensin-converting enzyme 2 (ACE2), in a tissue specific manner. The role of this association in relation to the formation of a functional unit related to Na+ or amino acid transport will be assessed. We will conclude with some remarks concerning the relevance of this association to Hartnup disorder, where some mutations have been shown to differentially interact with the partner proteins. |
| doi_str_mv | 10.4161/chan.5.5.16470 |
| format | Article |
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| ispartof | Channels (Austin, Tex.), 2011-09, Vol.5 (5), p.410-423 |
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| subjects | Agricultural sciences Amino Acid Transport Systems, Neutral - genetics Amino Acid Transport Systems, Neutral - metabolism Amino Acids - genetics Amino Acids - metabolism Animals Binding Biological Transport - physiology Biology Bioscience Calcium Cancer Cell Cycle Hartnup Disease - genetics Hartnup Disease - metabolism Humans Intestine, Small - metabolism Kidney - metabolism Landes Life Sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Organ Specificity - physiology Organogenesis Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Proteins Renin-Angiotensin System - physiology Sodium - metabolism |
| title | Collectrin and ACE2 in renal and intestinal amino acid transport |
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