Predicting the photostability characteristics of active pharmaceutical ingredients using electron paramagnetic resonance spectroscopy

Objective: The purpose of this study was to determine if electron paramagnetic resonance (EPR) spectroscopy could be used to develop a quick method to predict the longer-term photostability characteristics of active pharmaceutical ingredients (APIs) for use in the early development phase. Materials...

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Veröffentlicht in:	Drug development and industrial pharmacy 2012-02, Vol.38 (2), p.200-208
Hauptverfasser:	Williams, Helen Elizabeth, Claybourn, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Stability Electron Spin Resonance Spectroscopy - methods free radicals Free Radicals - chemistry Light pharmaceutical Pharmaceutical Preparations - chemistry Photochemistry Photodegradation Photolysis - radiation effects prediction Predictive Value of Tests Regression Analysis singlet oxygen Singlet Oxygen - chemistry Time Factors
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