Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans

Thiazolyl peptides are bacterial secondary metabolites that potently inhibit protein synthesis in Gram-positive bacteria and malarial parasites. Recently, our laboratory and others reported that this class of trithiazolyl pyridine-containing natural products is derived from ribosomally synthesized p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-08, Vol.108 (32), p.13053-13058
Hauptverfasser:	Young, Travis S, Walsh, Christopher T
Format:	Artikel
Sprache:	eng
Schlagworte:	alanine Amino acids Anti-Bacterial Agents - pharmacology antibacterial properties Antibiotics Bacteria Biological Sciences Biosynthesis Biosynthetic Pathways - drug effects Biosynthetic Pathways - genetics Chromatography, Liquid Computational Biology DNA Enzymes Gene Expression - drug effects gene targeting genetic engineering Gram-positive bacteria heterologous gene expression hydroxylation Hydroxyproline - metabolism isoleucine isotopes Libraries macrocyclic compounds Mass Spectrometry Metabolites Molecular Sequence Data Multigene family Multigene Family - genetics Mutation Oxidation Oxidation-Reduction - drug effects Parasites Peptides Peptides, Cyclic - chemistry Peptides, Cyclic - genetics Peptides, Cyclic - pharmacology Post translational modification Protein synthesis Rigidity Secondary metabolites Sequence Analysis, Protein Streptomyces Streptomyces - drug effects Streptomyces - genetics Streptomyces lividans Streptomyces lividans - drug effects Streptomyces lividans - genetics Streptomyces lividans - metabolism structure-activity relationships Thiazoles - chemistry Thiazoles - pharmacology
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