Glutathione modulates Ca(2+) influx and oxidative toxicity through TRPM2 channel in rat dorsal root ganglion neurons

Glutathione (GSH) is the most abundant thiol antioxidant in mammalian cells and maintains thiol redox in the cells. GSH depletion has been implicated in the neurobiology of sensory neurons. Because the mechanisms that lead to melastatin-like transient receptor potential 2 (TRPM2) channel activation/...

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Veröffentlicht in:	The Journal of membrane biology 2011-08, Vol.242 (3), p.109
Hauptverfasser:	Nazıroğlu, Mustafa, Özgül, Cemil, Çiğ, Bilal, Doğan, Salih, Uğuz, Abdulhadi Cihangir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Boron Compounds - pharmacology Buthionine Sulfoximine - pharmacology Calcium - metabolism Cytosol - metabolism Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Glutathione - metabolism Hydrogen Peroxide - pharmacology Ion Channels - metabolism Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Male Oxidative Stress - drug effects Oxidative Stress - physiology Rats Rats, Wistar Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism TRPM Cation Channels - antagonists & inhibitors TRPM Cation Channels - metabolism
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