Topical application of liposomal cobalamin hydrogel for atopic dermatitis therapy

Topical vitamin B12 was shown to be effective for atopic dermatitis. However, vitamin B12 itself is light sensitive and has low skin permeability, thus reducing its therapeutic effectiveness. In the present study, we prepared a liposomal hydrogel of adenosylcobalamin (AdCbl), a vitamin B12 derivativ...

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Veröffentlicht in:	Pharmazie 2011-06, Vol.66 (6), p.430-435
Hauptverfasser:	Jung, Suk Hyun, Cho, Young Sik, Jun, Sung Soo, Koo, Ja Seong, Cheon, Hyae Gyeong, Shin, Byung Cheol
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Buffers Dermatitis, Atopic - drug therapy Dermatitis, Atopic - pathology Diffusion Chambers, Culture Dinitrochlorobenzene Drug Carriers Female Hydrogel, Polyethylene Glycol Dimethacrylate Hydrogels Hydrogen-Ion Concentration Immunoglobulin E - blood In Vitro Techniques Irritants Liposomes Mice Mice, Inbred BALB C Particle Size Permeability Skin - pathology Skin Absorption Vitamin B 12 - administration & dosage Vitamin B 12 - therapeutic use
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