Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C(14)-erythromycin breath test and the antipyrine clearance test

Docetaxel has marked inter-patient PK variability, and metabolic phenotypic probes may enable individualised dosing. This is the first report directly comparing the erythromycin breath test (EBT) (a CYP3A4 probe) with the antipyrine clearance test (ACT), (a general CYP-P450/predominant CYP3A4 probe)...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2012-01, Vol.69 (1), p.125
Hauptverfasser:	Michael, M, Cullinane, C, Hatzimihalis, A, O'Kane, C, Milner, A, Booth, R, Schlicht, S, Clarke, S J, Francis, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antipyrine - pharmacokinetics Area Under Curve Breath Tests - methods Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 Enzyme System - metabolism Docetaxel Dose-Response Relationship, Drug Erythromycin - pharmacokinetics Female Humans Male Middle Aged Phenotype Taxoids - administration & dosage Taxoids - pharmacokinetics
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