Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness

Binding of a neurotransmitter to its membrane receptor opens an integral ion conducting pore. However, prolonged exposure to the neurotransmitter drives the receptor to a refractory state termed desensitization, which plays an important role in shaping synaptic transmission. Despite intensive resear...

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Veröffentlicht in:	The Journal of biological chemistry 2011-07, Vol.286 (28), p.25331
Hauptverfasser:	Zhang, Jianliang, Xue, Fenqin, Whiteaker, Paul, Li, Chaokun, Wu, Wen, Shen, Benchang, Huang, Yao, Lukas, Ronald J, Chang, Yongchang
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha7 Nicotinic Acetylcholine Receptor Animals Gene Expression Humans Ion Channel Gating - physiology Mutagenesis Protein Structure, Secondary Protein Structure, Tertiary Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism Structure-Activity Relationship Xenopus laevis
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