Regulation of Glutathione S-Transferase Ya Subunit Gene Expression: Identification of a Unique Xenobiotic-Responsive Element Controlling Inducible Expression by Planar Aromatic Compounds
We have identified a region in the 5' flanking sequence of the glutathione S-transferase (RX:glutathione R-transferase, EC 2.5.1.18) Ya subunit gene that contains a unique xenobiotic-responsive element (XRE). The regulatory region spans nucleotides -722 to -682 of the 5' flanking sequence...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1990-05, Vol.87 (10), p.3826-3830 |
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| creator | Rushmore, Thomas H. King, Ron G. Paulson, K. Eric Pickett, Cecil B. |
| description | We have identified a region in the 5' flanking sequence of the glutathione S-transferase (RX:glutathione R-transferase, EC 2.5.1.18) Ya subunit gene that contains a unique xenobiotic-responsive element (XRE). The regulatory region spans nucleotides -722 to -682 of the 5' flanking sequence and is responsible for part of the basal level as well as inducible expression of the Ya subunit gene by planar aromatic compounds such as β-naphthoflavone (β-NF) and 3-methylcholanthrene. The DNA sequence of this region (β-NF-responsive element) is distinct from the DNA sequence of the XRE found in the cytochrone P-450 IA1 gene. In addition to the region containing the β-NF-responsive element, two other regulatory regions of the Ya subunit gene have been identified. One region spans nucleotides -867 to -857 and has a DNA sequence with identity to the hepatocyte nuclear factor 1 recognition motif found in several liver-specific genes. The second region spans nucleotides -908 to -899 and contains a DNA sequence with identity to the XRE found in the cytochrome P-450 IA1 gene. The XRE sequence also contributes to part of the responsiveness of the Ya subunit gene to planar aromatic compounds. Our data suggest that regulation of gene expression by planar aromatic compounds can be mediated by a DNA sequence that is distinct from the XRE sequence. |
| doi_str_mv | 10.1073/pnas.87.10.3826 |
| format | Article |
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Eric ; Pickett, Cecil B.</creator><creatorcontrib>Rushmore, Thomas H. ; King, Ron G. ; Paulson, K. Eric ; Pickett, Cecil B.</creatorcontrib><description>We have identified a region in the 5' flanking sequence of the glutathione S-transferase (RX:glutathione R-transferase, EC 2.5.1.18) Ya subunit gene that contains a unique xenobiotic-responsive element (XRE). The regulatory region spans nucleotides -722 to -682 of the 5' flanking sequence and is responsible for part of the basal level as well as inducible expression of the Ya subunit gene by planar aromatic compounds such as β-naphthoflavone (β-NF) and 3-methylcholanthrene. The DNA sequence of this region (β-NF-responsive element) is distinct from the DNA sequence of the XRE found in the cytochrone P-450 IA1 gene. In addition to the region containing the β-NF-responsive element, two other regulatory regions of the Ya subunit gene have been identified. One region spans nucleotides -867 to -857 and has a DNA sequence with identity to the hepatocyte nuclear factor 1 recognition motif found in several liver-specific genes. The second region spans nucleotides -908 to -899 and contains a DNA sequence with identity to the XRE found in the cytochrome P-450 IA1 gene. The XRE sequence also contributes to part of the responsiveness of the Ya subunit gene to planar aromatic compounds. Our data suggest that regulation of gene expression by planar aromatic compounds can be mediated by a DNA sequence that is distinct from the XRE sequence.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.87.10.3826</identifier><identifier>PMID: 2160079</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550201 - Biochemistry- Tracer Techniques ; Aromatic compounds ; AROMATICS ; Base Sequence ; BASIC BIOLOGICAL SCIENCES ; Benzoflavones - pharmacology ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; beta-Naphthoflavone ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; Carcinoma, Hepatocellular ; Cell Line ; Cell lines ; Cell Nucleus - metabolism ; Chromosome Deletion ; Cloning, Molecular ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DNA ; DNA SEQUENCING ; Drug regulation ; DRUGS ; ENZYMES ; FLAVENOIDS ; FLAVONES ; Flavonoids - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Enzymologic - drug effects ; GENE REGULATION ; GENES ; Genes, Regulator - drug effects ; GLUTATHIONE ; Glutathione Transferase - genetics ; Hep G2 cells ; Humans ; ISOTOPES ; LIGHT NUCLEI ; Liver Neoplasms ; Macromolecular Substances ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Mutation ; Nuclear Proteins - metabolism ; NUCLEI ; NUCLEIC ACIDS ; Nucleotide sequences ; Nucleotides ; ODD-ODD NUCLEI ; Oligonucleotide Probes ; OLIGONUCLEOTIDES ; ORGANIC COMPOUNDS ; ORGANIC OXYGEN COMPOUNDS ; PEPTIDES ; PHOSPHORUS 32 ; PHOSPHORUS ISOTOPES ; POLYPEPTIDES ; PROTEINS ; RADIOISOTOPES ; RADIOPROTECTIVE SUBSTANCES ; Regional identity ; SCINTILLATION COUNTING ; STRUCTURAL CHEMICAL ANALYSIS ; Transcription. Transcription factor. Splicing. Rna processing ; Transfection ; TRANSFERASES ; XENOBIOTICS ; Xenobiotics - pharmacology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1990-05, Vol.87 (10), p.3826-3830</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-cb82eadf65d38d5c789318a21874408b49682cbab2af129f4a3f38bcf21e1df73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/87/10.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2354473$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2354473$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19450411$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2160079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5451501$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Rushmore, Thomas H.</creatorcontrib><creatorcontrib>King, Ron G.</creatorcontrib><creatorcontrib>Paulson, K. Eric</creatorcontrib><creatorcontrib>Pickett, Cecil B.</creatorcontrib><title>Regulation of Glutathione S-Transferase Ya Subunit Gene Expression: Identification of a Unique Xenobiotic-Responsive Element Controlling Inducible Expression by Planar Aromatic Compounds</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>We have identified a region in the 5' flanking sequence of the glutathione S-transferase (RX:glutathione R-transferase, EC 2.5.1.18) Ya subunit gene that contains a unique xenobiotic-responsive element (XRE). The regulatory region spans nucleotides -722 to -682 of the 5' flanking sequence and is responsible for part of the basal level as well as inducible expression of the Ya subunit gene by planar aromatic compounds such as β-naphthoflavone (β-NF) and 3-methylcholanthrene. The DNA sequence of this region (β-NF-responsive element) is distinct from the DNA sequence of the XRE found in the cytochrone P-450 IA1 gene. In addition to the region containing the β-NF-responsive element, two other regulatory regions of the Ya subunit gene have been identified. One region spans nucleotides -867 to -857 and has a DNA sequence with identity to the hepatocyte nuclear factor 1 recognition motif found in several liver-specific genes. The second region spans nucleotides -908 to -899 and contains a DNA sequence with identity to the XRE found in the cytochrome P-450 IA1 gene. The XRE sequence also contributes to part of the responsiveness of the Ya subunit gene to planar aromatic compounds. Our data suggest that regulation of gene expression by planar aromatic compounds can be mediated by a DNA sequence that is distinct from the XRE sequence.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>Aromatic compounds</subject><subject>AROMATICS</subject><subject>Base Sequence</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Benzoflavones - pharmacology</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>beta-Naphthoflavone</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>Carcinoma, Hepatocellular</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cell Nucleus - metabolism</subject><subject>Chromosome Deletion</subject><subject>Cloning, Molecular</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DNA</subject><subject>DNA SEQUENCING</subject><subject>Drug regulation</subject><subject>DRUGS</subject><subject>ENZYMES</subject><subject>FLAVENOIDS</subject><subject>FLAVONES</subject><subject>Flavonoids - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Enzymologic - drug effects</subject><subject>GENE REGULATION</subject><subject>GENES</subject><subject>Genes, Regulator - drug effects</subject><subject>GLUTATHIONE</subject><subject>Glutathione Transferase - genetics</subject><subject>Hep G2 cells</subject><subject>Humans</subject><subject>ISOTOPES</subject><subject>LIGHT NUCLEI</subject><subject>Liver Neoplasms</subject><subject>Macromolecular Substances</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Nuclear Proteins - metabolism</subject><subject>NUCLEI</subject><subject>NUCLEIC ACIDS</subject><subject>Nucleotide sequences</subject><subject>Nucleotides</subject><subject>ODD-ODD NUCLEI</subject><subject>Oligonucleotide Probes</subject><subject>OLIGONUCLEOTIDES</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC OXYGEN COMPOUNDS</subject><subject>PEPTIDES</subject><subject>PHOSPHORUS 32</subject><subject>PHOSPHORUS ISOTOPES</subject><subject>POLYPEPTIDES</subject><subject>PROTEINS</subject><subject>RADIOISOTOPES</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>Regional identity</subject><subject>SCINTILLATION COUNTING</subject><subject>STRUCTURAL CHEMICAL ANALYSIS</subject><subject>Transcription. Transcription factor. Splicing. Rna processing</subject><subject>Transfection</subject><subject>TRANSFERASES</subject><subject>XENOBIOTICS</subject><subject>Xenobiotics - pharmacology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1u1DAUhSMEKkNhzQaQhQSsMrUTJ7ERm2pUhpEqgfojwcpyHHvGlWMH26naV-vT1dEM03bDKro63zn3JLlZ9hbBOYJNeTRYHuakScO8JEX9LJshSFFeYwqfZzMIiyYnuMAvs1chXEEIaUXgQXZQoBrChs6yuzO5Hg2P2lngFFiaMfK4SZME5_mF5zYo6XmQ4A8H52M7Wh3BUib15GbwMoREfgWrTtqolRb7HA4urf47SvBbWtdqF7XIz2QYnA36OpmN7JMFLJyN3hmj7RqsbDcK3ZrH0aC9Bb8Mt9yDY-_6FC-Spx_caLvwOnuhuAnyze55mF1-P7lY_MhPfy5Xi-PTXFSIxly0pJC8U3XVlaSrRENoiQgvEGkwhqTFtCaFaHlbcIUKqjAvVUlaoQokUaea8jD7ts0dxraXnUjFPTds8Lrn_pY5rtlTxeoNW7trVpWU1sn-cWt3IWoWhI5SbISzVorIKlyhCqIEfd7t8C59thBZr4OQJr27dGNgqGoQqusigUdbUHgXgpdq3wNBNl0Emy6CkWaap4tIjveP6-_53Qkk_dNO50Fwo9I_Fzo8xFJcQYymih923LTgn_xk0Zf_AkyNxkR5ExP5bktehej8Q6Oywrgpy3sXpuY1</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Rushmore, Thomas H.</creator><creator>King, Ron G.</creator><creator>Paulson, K. Eric</creator><creator>Pickett, Cecil B.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19900501</creationdate><title>Regulation of Glutathione S-Transferase Ya Subunit Gene Expression: Identification of a Unique Xenobiotic-Responsive Element Controlling Inducible Expression by Planar Aromatic Compounds</title><author>Rushmore, Thomas H. ; King, Ron G. ; Paulson, K. Eric ; Pickett, Cecil B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-cb82eadf65d38d5c789318a21874408b49682cbab2af129f4a3f38bcf21e1df73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>Aromatic compounds</topic><topic>AROMATICS</topic><topic>Base Sequence</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Benzoflavones - pharmacology</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>beta-Naphthoflavone</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>Carcinoma, Hepatocellular</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cell Nucleus - metabolism</topic><topic>Chromosome Deletion</topic><topic>Cloning, Molecular</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DNA</topic><topic>DNA SEQUENCING</topic><topic>Drug regulation</topic><topic>DRUGS</topic><topic>ENZYMES</topic><topic>FLAVENOIDS</topic><topic>FLAVONES</topic><topic>Flavonoids - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Enzymologic - drug effects</topic><topic>GENE REGULATION</topic><topic>GENES</topic><topic>Genes, Regulator - drug effects</topic><topic>GLUTATHIONE</topic><topic>Glutathione Transferase - genetics</topic><topic>Hep G2 cells</topic><topic>Humans</topic><topic>ISOTOPES</topic><topic>LIGHT NUCLEI</topic><topic>Liver Neoplasms</topic><topic>Macromolecular Substances</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Nuclear Proteins - metabolism</topic><topic>NUCLEI</topic><topic>NUCLEIC ACIDS</topic><topic>Nucleotide sequences</topic><topic>Nucleotides</topic><topic>ODD-ODD NUCLEI</topic><topic>Oligonucleotide Probes</topic><topic>OLIGONUCLEOTIDES</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC OXYGEN COMPOUNDS</topic><topic>PEPTIDES</topic><topic>PHOSPHORUS 32</topic><topic>PHOSPHORUS ISOTOPES</topic><topic>POLYPEPTIDES</topic><topic>PROTEINS</topic><topic>RADIOISOTOPES</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>Regional identity</topic><topic>SCINTILLATION COUNTING</topic><topic>STRUCTURAL CHEMICAL ANALYSIS</topic><topic>Transcription. Transcription factor. Splicing. Rna processing</topic><topic>Transfection</topic><topic>TRANSFERASES</topic><topic>XENOBIOTICS</topic><topic>Xenobiotics - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rushmore, Thomas H.</creatorcontrib><creatorcontrib>King, Ron G.</creatorcontrib><creatorcontrib>Paulson, K. Eric</creatorcontrib><creatorcontrib>Pickett, Cecil B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rushmore, Thomas H.</au><au>King, Ron G.</au><au>Paulson, K. Eric</au><au>Pickett, Cecil B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of Glutathione S-Transferase Ya Subunit Gene Expression: Identification of a Unique Xenobiotic-Responsive Element Controlling Inducible Expression by Planar Aromatic Compounds</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>87</volume><issue>10</issue><spage>3826</spage><epage>3830</epage><pages>3826-3830</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>We have identified a region in the 5' flanking sequence of the glutathione S-transferase (RX:glutathione R-transferase, EC 2.5.1.18) Ya subunit gene that contains a unique xenobiotic-responsive element (XRE). The regulatory region spans nucleotides -722 to -682 of the 5' flanking sequence and is responsible for part of the basal level as well as inducible expression of the Ya subunit gene by planar aromatic compounds such as β-naphthoflavone (β-NF) and 3-methylcholanthrene. The DNA sequence of this region (β-NF-responsive element) is distinct from the DNA sequence of the XRE found in the cytochrone P-450 IA1 gene. In addition to the region containing the β-NF-responsive element, two other regulatory regions of the Ya subunit gene have been identified. One region spans nucleotides -867 to -857 and has a DNA sequence with identity to the hepatocyte nuclear factor 1 recognition motif found in several liver-specific genes. The second region spans nucleotides -908 to -899 and contains a DNA sequence with identity to the XRE found in the cytochrome P-450 IA1 gene. The XRE sequence also contributes to part of the responsiveness of the Ya subunit gene to planar aromatic compounds. Our data suggest that regulation of gene expression by planar aromatic compounds can be mediated by a DNA sequence that is distinct from the XRE sequence.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2160079</pmid><doi>10.1073/pnas.87.10.3826</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1990-05, Vol.87 (10), p.3826-3830 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmed_primary_2160079 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 550201 - Biochemistry- Tracer Techniques Aromatic compounds AROMATICS Base Sequence BASIC BIOLOGICAL SCIENCES Benzoflavones - pharmacology BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES beta-Naphthoflavone Biological and medical sciences BIOLOGICAL EFFECTS Carcinoma, Hepatocellular Cell Line Cell lines Cell Nucleus - metabolism Chromosome Deletion Cloning, Molecular COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DNA DNA SEQUENCING Drug regulation DRUGS ENZYMES FLAVENOIDS FLAVONES Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - drug effects GENE REGULATION GENES Genes, Regulator - drug effects GLUTATHIONE Glutathione Transferase - genetics Hep G2 cells Humans ISOTOPES LIGHT NUCLEI Liver Neoplasms Macromolecular Substances Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutation Nuclear Proteins - metabolism NUCLEI NUCLEIC ACIDS Nucleotide sequences Nucleotides ODD-ODD NUCLEI Oligonucleotide Probes OLIGONUCLEOTIDES ORGANIC COMPOUNDS ORGANIC OXYGEN COMPOUNDS PEPTIDES PHOSPHORUS 32 PHOSPHORUS ISOTOPES POLYPEPTIDES PROTEINS RADIOISOTOPES RADIOPROTECTIVE SUBSTANCES Regional identity SCINTILLATION COUNTING STRUCTURAL CHEMICAL ANALYSIS Transcription. Transcription factor. Splicing. Rna processing Transfection TRANSFERASES XENOBIOTICS Xenobiotics - pharmacology |
| title | Regulation of Glutathione S-Transferase Ya Subunit Gene Expression: Identification of a Unique Xenobiotic-Responsive Element Controlling Inducible Expression by Planar Aromatic Compounds |
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