Up-regulation of T lymphocyte and antibody production by inflammatory cytokines released by macrophage exposure to multi-walled carbon nanotubes

Our data demonstrate that multi-walled carbon nanotubes (MWCNTs) are internalized by macrophages, subsequently activating them to produce interleukin (IL)-12 (IL-12). This cytokine induced the proliferative response of T lymphocytes to a nonspecific mitogen and to ovalbumin (OVA). This increase in t...

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Veröffentlicht in:	Nanotechnology 2011-07, Vol.22 (26), p.265103-265103
Hauptverfasser:	Grecco, Ana Carolina P, Paula, Rosemeire F O, Mizutani, Erica, Sartorelli, Juliana C, Milani, Ana M, Longhini, Ana Leda F, Oliveira, Elaine C, Pradella, Fernando, Silva, Vania D R, Moraes, Adriel S, Peterlevitz, Alfredo C, Farias, Alessandro S, Ceragioli, Helder J, Santos, Leonilda M B, Baranauskas, Vitor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - immunology Antigens - immunology B-Lymphocytes - immunology Cytokines - secretion Endocytosis Gene Expression Regulation Inflammation Mediators - metabolism Interleukin-12 - genetics Interleukin-12 - metabolism Lymphocyte Activation - immunology Macrophage Activation - immunology Macrophages - secretion Mice Mice, Inbred C57BL Nanotubes, Carbon - chemistry Nanotubes, Carbon - ultrastructure Ovalbumin - immunology Spectrum Analysis, Raman T-Lymphocytes - immunology Up-Regulation - immunology
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