Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors
ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors. These proteins direct gene expression in diverse normal and disease states by binding to specific promoters and enhancers and facilitating assembly of other components of the transcriptional machinery. The highl...
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| Veröffentlicht in: | Annual review of biochemistry 2011-01, Vol.80 (1), p.437-471 |
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| creator | Hollenhorst, Peter C McIntosh, Lawrence P Graves, Barbara J |
| description | ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors. These proteins direct gene expression in diverse normal and disease states by binding to specific promoters and enhancers and facilitating assembly of other components of the transcriptional machinery. The highly conserved DNA-binding ETS domain defines the family and is responsible for specific recognition of a common sequence motif, 5′-GGA(A T)-3′. Attaining specificity for biological regulation in such a family is thus a conundrum. We present the current knowledge of routes to functional diversity and DNA binding specificity, including divergent properties of the conserved ETS and PNT domains, the involvement of flanking structured and unstructured regions appended to these dynamic domains, posttranslational modifications, and protein partnerships with other DNA-binding proteins and coregulators. The review emphasizes recent advances from biochemical and biophysical approaches, as well as insights from genomic studies that detect ETS-factor occupancy in living cells. |
| doi_str_mv | 10.1146/annurev.biochem.79.081507.103945 |
| format | Article |
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These proteins direct gene expression in diverse normal and disease states by binding to specific promoters and enhancers and facilitating assembly of other components of the transcriptional machinery. The highly conserved DNA-binding ETS domain defines the family and is responsible for specific recognition of a common sequence motif, 5′-GGA(A T)-3′. Attaining specificity for biological regulation in such a family is thus a conundrum. We present the current knowledge of routes to functional diversity and DNA binding specificity, including divergent properties of the conserved ETS and PNT domains, the involvement of flanking structured and unstructured regions appended to these dynamic domains, posttranslational modifications, and protein partnerships with other DNA-binding proteins and coregulators. 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All rights reserved 2011</rights><rights>Copyright Annual Reviews, Inc. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a564t-d9447bf57a3649da1c8ad4036bfe99193f44079f074293b51c836870170611573</citedby><cites>FETCH-LOGICAL-a564t-d9447bf57a3649da1c8ad4036bfe99193f44079f074293b51c836870170611573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.biochem.79.081507.103945?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.biochem.79.081507.103945$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,230,314,780,784,885,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21548782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hollenhorst, Peter C</creatorcontrib><creatorcontrib>McIntosh, Lawrence P</creatorcontrib><creatorcontrib>Graves, Barbara J</creatorcontrib><title>Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors</title><title>Annual review of biochemistry</title><addtitle>Annu Rev Biochem</addtitle><description>ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors. These proteins direct gene expression in diverse normal and disease states by binding to specific promoters and enhancers and facilitating assembly of other components of the transcriptional machinery. The highly conserved DNA-binding ETS domain defines the family and is responsible for specific recognition of a common sequence motif, 5′-GGA(A T)-3′. Attaining specificity for biological regulation in such a family is thus a conundrum. We present the current knowledge of routes to functional diversity and DNA binding specificity, including divergent properties of the conserved ETS and PNT domains, the involvement of flanking structured and unstructured regions appended to these dynamic domains, posttranslational modifications, and protein partnerships with other DNA-binding proteins and coregulators. The review emphasizes recent advances from biochemical and biophysical approaches, as well as insights from genomic studies that detect ETS-factor occupancy in living cells.</description><subject>Animals</subject><subject>autoinhibition</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Biochemistry</subject><subject>Cells</subject><subject>ChIP-Seq</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>DNA - genetics</subject><subject>DNA - metabolism</subject><subject>DNA binding</subject><subject>ETS domain</subject><subject>Gene expression</subject><subject>Genome</subject><subject>Humans</subject><subject>Models, Molecular</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Phylogeny</subject><subject>PNT domain</subject><subject>Protein Binding</subject><subject>Protein Conformation</subject><subject>protein dynamics</subject><subject>Protein Multimerization</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-ets - chemistry</subject><subject>Proto-Oncogene Proteins c-ets - classification</subject><subject>Proto-Oncogene Proteins c-ets - genetics</subject><subject>Proto-Oncogene Proteins c-ets - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Transcription, Genetic</subject><issn>0066-4154</issn><issn>1545-4509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU1rFDEYgINY7Fr9CxK86GXGZPI1uYi1bGuhUGjXc8hkMt2UmWRNMpX-e7PMWtSL9BR48_Dk4wHgI0Y1xpR_0t7P0T7UnQtma6dayBq1mCFRY0QkZS_ACjPKKsqQfAlWCHFe0TI5Bq9TukdoDzWvwHFTZq1omxW4ubA-TM5A7Xv4ddE6o0d46ZO72-YEnc8B5q2Ftztr3OCMy48wDHC9uYWbqH0y0e2yCx6ea5NDTG_A0aDHZN8e1hPw_Xy9OftWXV1fXJ6dXlWacZqrXlIquoEJTTiVvcam1T1FhHeDlRJLMlCKhByQoI0kHSv7hLcCYYE4xkyQE_B58e7mbrK9sT5HPapddJOOjypop_7e8W6r7sKDYoy3nJMi-HAQxPBjtimrySVjx1F7G-akJBJYYCT5f8lWNJQwyVkh3_9D3oc5-vIPBaINbgiRBfqyQCaGlKIdni6NkdqHVofQ6hBaCamW0GoJXRTv_nz8k-B32QKsF2Cv0mOROfszPf-gX_P3wL8</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Hollenhorst, Peter C</creator><creator>McIntosh, Lawrence P</creator><creator>Graves, Barbara J</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors</title><author>Hollenhorst, Peter C ; McIntosh, Lawrence P ; Graves, Barbara J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a564t-d9447bf57a3649da1c8ad4036bfe99193f44079f074293b51c836870170611573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>autoinhibition</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Biochemistry</topic><topic>Cells</topic><topic>ChIP-Seq</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - chemistry</topic><topic>DNA - genetics</topic><topic>DNA - metabolism</topic><topic>DNA binding</topic><topic>ETS domain</topic><topic>Gene expression</topic><topic>Genome</topic><topic>Humans</topic><topic>Models, Molecular</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Phylogeny</topic><topic>PNT domain</topic><topic>Protein Binding</topic><topic>Protein Conformation</topic><topic>protein dynamics</topic><topic>Protein Multimerization</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins c-ets - chemistry</topic><topic>Proto-Oncogene Proteins c-ets - classification</topic><topic>Proto-Oncogene Proteins c-ets - genetics</topic><topic>Proto-Oncogene Proteins c-ets - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hollenhorst, Peter C</creatorcontrib><creatorcontrib>McIntosh, Lawrence P</creatorcontrib><creatorcontrib>Graves, Barbara J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annual review of biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hollenhorst, Peter C</au><au>McIntosh, Lawrence P</au><au>Graves, Barbara J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors</atitle><jtitle>Annual review of biochemistry</jtitle><addtitle>Annu Rev Biochem</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>80</volume><issue>1</issue><spage>437</spage><epage>471</epage><pages>437-471</pages><issn>0066-4154</issn><eissn>1545-4509</eissn><coden>ARBOAW</coden><abstract>ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors. 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| subjects | Animals autoinhibition Base Sequence Binding Sites Biochemistry Cells ChIP-Seq Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism DNA binding ETS domain Gene expression Genome Humans Models, Molecular Molecular Sequence Data Multigene Family Phylogeny PNT domain Protein Binding Protein Conformation protein dynamics Protein Multimerization Proteins Proto-Oncogene Proteins c-ets - chemistry Proto-Oncogene Proteins c-ets - classification Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Signal Transduction - physiology Transcription, Genetic |
| title | Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors |
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