Exploring transcription regulation through cell-to-cell variability

The regulation of cellular protein levels is a complex process involving many regulatory mechanisms, each introducing stochastic events, leading to variability of protein levels between isogenic cells. Previous studies have shown that perturbing genes involved in transcription regulation affects the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-04, Vol.108 (15), p.6329-6334
Hauptverfasser:	Rinott, Ruty, Jaimovich, Ariel, Friedman, Nir
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Sciences Chromatin Datasets Deoxyribonucleic acid DNA Flow Cytometry fluorescence Gene Deletion Gene expression Gene Expression Regulation, Fungal Genes Genetic screening Genetic Variation Genotype & phenotype Luminescent Proteins - biosynthesis Luminescent Proteins - genetics Morphology Phenotype Phenotypes Promoter Regions, Genetic Protein Biosynthesis - genetics Protein synthesis Proteins Red Fluorescent Protein Ribonucleases - genetics Ribonucleases - metabolism RNA RNA, Transfer - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Statistical variance transcription (genetics) Transcription, Genetic Transcriptional regulatory elements Transfer RNA transport proteins Yeast
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