2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro

: Chloracne is a characteristic marker of intoxication by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) or related compounds. Decreased lipogenesis is a prominent clinical sign in this disease. However, the activity of dioxins on human sebaceous glands is still unclear. In this study, the effects of T...

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Veröffentlicht in:	Experimental dermatology 2011-04, Vol.20 (4), p.320-325
Hauptverfasser:	Ju, Qiang, Fimmel, Sabine, Hinz, Norbert, Stahlmann, Ralf, Xia, Longqing, Zouboulis, Christos C.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-tetrachlorodibenzo-p-dioxin Biological and medical sciences Cell Differentiation - drug effects Cells, Cultured chloracne Dermatology differentiation Humans Keratin-10 - metabolism Keratin-7 - metabolism Lipid Metabolism - drug effects Medical sciences Mucin-1 - metabolism Polychlorinated Dibenzodioxins - pharmacology PPAR delta - metabolism Receptors, Aryl Hydrocarbon - drug effects Receptors, Aryl Hydrocarbon - metabolism sebaceous gland Sebaceous Glands - cytology Sebaceous Glands - metabolism Signal Transduction Skin involvement in other diseases. Miscellaneous. General aspects skin physiology SZ95 sebocytes TCDD TCDD, 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
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