Pharmacological enhancement of δ-subunit-containing GABA A receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice

The development of new strategies for the treatment of acute pain requires the identification of novel nonopioid receptor targets. This study explored whether δ-subunit-containing GABA ARs (δGABA ARs) in neurons of the spinal cord dorsal horn generate a tonic inhibitory conductance in vitro and whet...

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Veröffentlicht in:	Pain (Amsterdam) 2011-06, Vol.152 (6), p.1317-1326
Hauptverfasser:	Bonin, Robert P., Labrakakis, Charalampos, Eng, David G., Whissell, Paul D., Koninck, Yves De, Orser, Beverley A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - genetics Analgesics - pharmacology Anesthetics - pharmacology Animals Bicuculline - pharmacology Desoxycorticosterone - analogs & derivatives Desoxycorticosterone - pharmacology Dorsal horn Dose-Response Relationship, Drug Electric Stimulation Formaldehyde - adverse effects GABA GABA-A Receptor Antagonists - pharmacology gamma-Aminobutyric Acid - pharmacology Hindlimb Suspension - methods In Vitro Techniques Inhibition Isoxazoles - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Neural Inhibition - drug effects Neural Inhibition - genetics Neural Inhibition - physiology Nociception Pain Measurement - drug effects Pain Measurement - methods Psychomotor Performance - drug effects Receptors, GABA-A - deficiency Receptors, GABA-A - metabolism Sensitization Sensory Receptor Cells - drug effects Sensory Receptor Cells - physiology Spinal Cord - cytology
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