Perivascular Nitric Oxide Delivery to Saphenous Vein Grafts Prevents Graft Stenosis after Coronary Artery Bypass Grafting: A Novel Sheep Model
Objectives: Graft stenosis is a major complication of coronary artery bypass grafting with autologous saphenous vein grafts. Nitric oxide (NO) is believed to prevent this phenomenon. We studied the effect of perivascular application of an NO donor on the degree of stenosis of such grafts in an ovine...
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| Veröffentlicht in: | Cardiology 2011-01, Vol.118 (1), p.8-15 |
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| creator | Abbasi, Kyomars Shalileh, Keivan Anvari, Maryam Sotudeh Rabbani, Shahram Mahdanian, Abolfazl Ahmadi, Seyed Hosein Moshtaghi, Naghmeh Movahedi, Namvar Karimi, Abbasali |
| description | Objectives: Graft stenosis is a major complication of coronary artery bypass grafting with autologous saphenous vein grafts. Nitric oxide (NO) is believed to prevent this phenomenon. We studied the effect of perivascular application of an NO donor on the degree of stenosis of such grafts in an ovine model. Methods: Twenty white Iranian ewes were randomized to coronary artery bypass grafting using autologous saphenous vein grafts with application of an elastomer gel containing diethylenetriamine NO adduct in 0.9% sodium chloride solution around the grafted vessel (intervention group) or with the gel containing the saline solution alone (controls). Graft vessels were studied after 1 year using spot angiography and histological examination. Results: The mean degree of stenosis was significantly lower in the intervention group than in the controls as found by histology (92.3 ± 5.5 vs. 80.9 ± 8.3%; p = 0.004). Although the difference in the angiographic score was not significant, the mean score was still lower in the intervention group (9.5 ± 11.3 vs. 12.0 ± 11.8). Conclusions: Perivascular application of an NO donor was, at least histologically, effective in reducing graft stenosis in our ovine model. This can be a step toward the development of drug-eluting coronary artery bypass grafts. |
| doi_str_mv | 10.1159/000324316 |
| format | Article |
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Nitric oxide (NO) is believed to prevent this phenomenon. We studied the effect of perivascular application of an NO donor on the degree of stenosis of such grafts in an ovine model. Methods: Twenty white Iranian ewes were randomized to coronary artery bypass grafting using autologous saphenous vein grafts with application of an elastomer gel containing diethylenetriamine NO adduct in 0.9% sodium chloride solution around the grafted vessel (intervention group) or with the gel containing the saline solution alone (controls). Graft vessels were studied after 1 year using spot angiography and histological examination. Results: The mean degree of stenosis was significantly lower in the intervention group than in the controls as found by histology (92.3 ± 5.5 vs. 80.9 ± 8.3%; p = 0.004). Although the difference in the angiographic score was not significant, the mean score was still lower in the intervention group (9.5 ± 11.3 vs. 12.0 ± 11.8). Conclusions: Perivascular application of an NO donor was, at least histologically, effective in reducing graft stenosis in our ovine model. This can be a step toward the development of drug-eluting coronary artery bypass grafts.</description><identifier>ISSN: 0008-6312</identifier><identifier>EISSN: 1421-9751</identifier><identifier>DOI: 10.1159/000324316</identifier><identifier>PMID: 21389715</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Coronary Artery Bypass ; Endothelium-Dependent Relaxing Factors - administration & dosage ; Female ; Graft Occlusion, Vascular - pathology ; Graft Occlusion, Vascular - prevention & control ; Heart surgery ; Nitric oxide ; Nitric Oxide - administration & dosage ; Nitrites - blood ; Original Research ; Pilot Projects ; Random Allocation ; Saphenous Vein - pathology ; Saphenous Vein - transplantation ; Sheep ; Skin & tissue grafts ; Transplantation, Autologous</subject><ispartof>Cardiology, 2011-01, Vol.118 (1), p.8-15</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-2948636ad88025d3a3d919b9dd8fad9a54138e423e3de45bc498426c822679a83</citedby><cites>FETCH-LOGICAL-c332t-2948636ad88025d3a3d919b9dd8fad9a54138e423e3de45bc498426c822679a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21389715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abbasi, Kyomars</creatorcontrib><creatorcontrib>Shalileh, Keivan</creatorcontrib><creatorcontrib>Anvari, Maryam Sotudeh</creatorcontrib><creatorcontrib>Rabbani, Shahram</creatorcontrib><creatorcontrib>Mahdanian, Abolfazl</creatorcontrib><creatorcontrib>Ahmadi, Seyed Hosein</creatorcontrib><creatorcontrib>Moshtaghi, Naghmeh</creatorcontrib><creatorcontrib>Movahedi, Namvar</creatorcontrib><creatorcontrib>Karimi, Abbasali</creatorcontrib><title>Perivascular Nitric Oxide Delivery to Saphenous Vein Grafts Prevents Graft Stenosis after Coronary Artery Bypass Grafting: A Novel Sheep Model</title><title>Cardiology</title><addtitle>Cardiology</addtitle><description>Objectives: Graft stenosis is a major complication of coronary artery bypass grafting with autologous saphenous vein grafts. Nitric oxide (NO) is believed to prevent this phenomenon. We studied the effect of perivascular application of an NO donor on the degree of stenosis of such grafts in an ovine model. Methods: Twenty white Iranian ewes were randomized to coronary artery bypass grafting using autologous saphenous vein grafts with application of an elastomer gel containing diethylenetriamine NO adduct in 0.9% sodium chloride solution around the grafted vessel (intervention group) or with the gel containing the saline solution alone (controls). Graft vessels were studied after 1 year using spot angiography and histological examination. Results: The mean degree of stenosis was significantly lower in the intervention group than in the controls as found by histology (92.3 ± 5.5 vs. 80.9 ± 8.3%; p = 0.004). Although the difference in the angiographic score was not significant, the mean score was still lower in the intervention group (9.5 ± 11.3 vs. 12.0 ± 11.8). Conclusions: Perivascular application of an NO donor was, at least histologically, effective in reducing graft stenosis in our ovine model. This can be a step toward the development of drug-eluting coronary artery bypass grafts.</description><subject>Animals</subject><subject>Coronary Artery Bypass</subject><subject>Endothelium-Dependent Relaxing Factors - administration & dosage</subject><subject>Female</subject><subject>Graft Occlusion, Vascular - pathology</subject><subject>Graft Occlusion, Vascular - prevention & control</subject><subject>Heart surgery</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - administration & dosage</subject><subject>Nitrites - blood</subject><subject>Original Research</subject><subject>Pilot Projects</subject><subject>Random Allocation</subject><subject>Saphenous Vein - pathology</subject><subject>Saphenous Vein - transplantation</subject><subject>Sheep</subject><subject>Skin & tissue grafts</subject><subject>Transplantation, Autologous</subject><issn>0008-6312</issn><issn>1421-9751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtPGzEUha0KVMJjwb6qrG5QF1PGr4ndXUjLQ4IEKW23I2d8A4bJeLBnovIn-M1cmpBFV_axvnvkcw8hxyz_xpgyp3meCy4FKz6QAZOcZWao2A4Z4LvOCsH4HtlP6QGlHEr-kexxJrQZMjUgL7cQ_cqmqq9tpBPfRV_R6V_vgP6A2q8gPtMu0Jlt76EJfaJ_wDf0ItpFl-hthBU0ePmn6axDJPlEUUCk4xBDY3F-FLs3m7Pn1qYN65u773REJ2EFNZ3dA7T0JjioD8nuwtYJjjbnAfl9_vPX-DK7nl5cjUfXWSUE7zJupC5EYZ3WOVdOWOEMM3PjnF5YZ6ySGBAkFyAcSDWvpNGSF5XmvBgaq8UBOVn7tjE89ZC6culTBXVtG8CUpS447lQpjuSX_8iH0McGP4eQVBJ3KhH6uoaqGFKKsCjb6JeYvWR5-VZRua0I2c8bw36-BLcl3ztB4NMaeLTxDuIW2My_AnlwlDU</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Abbasi, Kyomars</creator><creator>Shalileh, Keivan</creator><creator>Anvari, Maryam Sotudeh</creator><creator>Rabbani, Shahram</creator><creator>Mahdanian, Abolfazl</creator><creator>Ahmadi, Seyed Hosein</creator><creator>Moshtaghi, Naghmeh</creator><creator>Movahedi, Namvar</creator><creator>Karimi, Abbasali</creator><general>S. 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Shalileh, Keivan ; Anvari, Maryam Sotudeh ; Rabbani, Shahram ; Mahdanian, Abolfazl ; Ahmadi, Seyed Hosein ; Moshtaghi, Naghmeh ; Movahedi, Namvar ; Karimi, Abbasali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-2948636ad88025d3a3d919b9dd8fad9a54138e423e3de45bc498426c822679a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Coronary Artery Bypass</topic><topic>Endothelium-Dependent Relaxing Factors - administration & dosage</topic><topic>Female</topic><topic>Graft Occlusion, Vascular - pathology</topic><topic>Graft Occlusion, Vascular - prevention & control</topic><topic>Heart surgery</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - administration & dosage</topic><topic>Nitrites - blood</topic><topic>Original Research</topic><topic>Pilot Projects</topic><topic>Random Allocation</topic><topic>Saphenous Vein - pathology</topic><topic>Saphenous Vein - transplantation</topic><topic>Sheep</topic><topic>Skin & tissue grafts</topic><topic>Transplantation, Autologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abbasi, Kyomars</creatorcontrib><creatorcontrib>Shalileh, Keivan</creatorcontrib><creatorcontrib>Anvari, Maryam Sotudeh</creatorcontrib><creatorcontrib>Rabbani, Shahram</creatorcontrib><creatorcontrib>Mahdanian, Abolfazl</creatorcontrib><creatorcontrib>Ahmadi, Seyed Hosein</creatorcontrib><creatorcontrib>Moshtaghi, Naghmeh</creatorcontrib><creatorcontrib>Movahedi, Namvar</creatorcontrib><creatorcontrib>Karimi, Abbasali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbasi, Kyomars</au><au>Shalileh, Keivan</au><au>Anvari, Maryam Sotudeh</au><au>Rabbani, Shahram</au><au>Mahdanian, Abolfazl</au><au>Ahmadi, Seyed Hosein</au><au>Moshtaghi, Naghmeh</au><au>Movahedi, Namvar</au><au>Karimi, Abbasali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perivascular Nitric Oxide Delivery to Saphenous Vein Grafts Prevents Graft Stenosis after Coronary Artery Bypass Grafting: A Novel Sheep Model</atitle><jtitle>Cardiology</jtitle><addtitle>Cardiology</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>118</volume><issue>1</issue><spage>8</spage><epage>15</epage><pages>8-15</pages><issn>0008-6312</issn><eissn>1421-9751</eissn><abstract>Objectives: Graft stenosis is a major complication of coronary artery bypass grafting with autologous saphenous vein grafts. Nitric oxide (NO) is believed to prevent this phenomenon. We studied the effect of perivascular application of an NO donor on the degree of stenosis of such grafts in an ovine model. Methods: Twenty white Iranian ewes were randomized to coronary artery bypass grafting using autologous saphenous vein grafts with application of an elastomer gel containing diethylenetriamine NO adduct in 0.9% sodium chloride solution around the grafted vessel (intervention group) or with the gel containing the saline solution alone (controls). Graft vessels were studied after 1 year using spot angiography and histological examination. Results: The mean degree of stenosis was significantly lower in the intervention group than in the controls as found by histology (92.3 ± 5.5 vs. 80.9 ± 8.3%; p = 0.004). Although the difference in the angiographic score was not significant, the mean score was still lower in the intervention group (9.5 ± 11.3 vs. 12.0 ± 11.8). Conclusions: Perivascular application of an NO donor was, at least histologically, effective in reducing graft stenosis in our ovine model. This can be a step toward the development of drug-eluting coronary artery bypass grafts.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21389715</pmid><doi>10.1159/000324316</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0008-6312 |
| ispartof | Cardiology, 2011-01, Vol.118 (1), p.8-15 |
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| language | eng |
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| source | MEDLINE; Karger Journals Complete; Alma/SFX Local Collection |
| subjects | Animals Coronary Artery Bypass Endothelium-Dependent Relaxing Factors - administration & dosage Female Graft Occlusion, Vascular - pathology Graft Occlusion, Vascular - prevention & control Heart surgery Nitric oxide Nitric Oxide - administration & dosage Nitrites - blood Original Research Pilot Projects Random Allocation Saphenous Vein - pathology Saphenous Vein - transplantation Sheep Skin & tissue grafts Transplantation, Autologous |
| title | Perivascular Nitric Oxide Delivery to Saphenous Vein Grafts Prevents Graft Stenosis after Coronary Artery Bypass Grafting: A Novel Sheep Model |
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