Expression of RNA of an Endogenous Replication-Defective Retrovirus in Rat Mammary Adenocarcinomas Induced by 7,12-Dimethylbenz[a]anthracene
An investigation into the possible relationship between chemical carcinogen Induction of rat mammary tumors and the expression of an endogenous retrovlral genome was Initiated. Mammary tumors were Induced In female SO rats with 7,12-dimethylbenz[a]anthracene (OMBA). Tumors, Identified histologically...
Gespeichert in:
| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1978-11, Vol.61 (5), p.1329-1337 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1337 |
|---|---|
| container_issue | 5 |
| container_start_page | 1329 |
| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 61 |
| creator | Young, Howard A. Wenk, Martin L. Goodman, Dawn G. Scolnick, Edward M. |
| description | An investigation into the possible relationship between chemical carcinogen Induction of rat mammary tumors and the expression of an endogenous retrovlral genome was Initiated. Mammary tumors were Induced In female SO rats with 7,12-dimethylbenz[a]anthracene (OMBA). Tumors, Identified histologically as mammary adenocarcinomas, were analyzed for RNA of a replication-defective endogenous retrovirus or RNA of a helper-independent endogenous type C virus. Expression of RNA of the replication-defective virus was detected In mammary tumors weighing 0.2–2.0 g. Larger tumors, for which histologic examination revealed proportionally more fibroblastic tissue than epithelial cells, did not contain comparable concentrations of this viral RNA. RNA homologous to a helper-independent rat type C retrovirus was not detected in tumors of any size. A cell line was established from a primary OMBA-induced mammary adenocarcinoma and appeared similar to the small mammary tumors with respect to endogenous type C viral RNA expression. We discuss possible implications of the expression of endogenous replication- defective viruses for use as markers for the effects of chemical carcinogens. |
| doi_str_mv | 10.1093/jnci/61.5.1329 |
| format | Article |
| fullrecord | <record><control><sourceid>istex_pubme</sourceid><recordid>TN_cdi_pubmed_primary_213614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_HXZ_FDG7031K_S</sourcerecordid><originalsourceid>FETCH-LOGICAL-i243t-77b499d6ff37851ff2f28f0c65279491c1f7c8d64c52044eb8fcece166592be03</originalsourceid><addsrcrecordid>eNo9kMtOwzAQRS3Eqzy2rFj4A0jxK3ayrGgLFQWkAhICochxxtSlcaI4RZRv4KMJKmI2V5pz79VoEDqhpE9Jys8X3rhzSftxn3KWbqEeFZJEjJJ4G_UIYSpKEiX20UEIC9JNysQe2mWUSyp66Hv0WTcQgqs8riye3Q5-RXs88kX1Br5aBTyDeumMbjtPNAQLpnUf0G3bpvpwTWdwHs90i290WepmjQdFlzO6Mc5XpQ544ouVgQLna6zOKIuGroR2vl7m4L9e9Kv27bzRBjwcoR2rlwGO__QQPY5HDxdX0fTucnIxmEaOCd5GSuUiTQtpLVdJTK1lliWWGBkzlYqUGmqVSQopTMyIEJAn1oABKmWcshwIP0Snm956lZdQZHXjfg_PNk_pcLTBLrTw-U91855JxVWcXT09Z-PhpSKcXmf3_AekMXTO</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Expression of RNA of an Endogenous Replication-Defective Retrovirus in Rat Mammary Adenocarcinomas Induced by 7,12-Dimethylbenz[a]anthracene</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><creator>Young, Howard A. ; Wenk, Martin L. ; Goodman, Dawn G. ; Scolnick, Edward M.</creator><creatorcontrib>Young, Howard A. ; Wenk, Martin L. ; Goodman, Dawn G. ; Scolnick, Edward M.</creatorcontrib><description>An investigation into the possible relationship between chemical carcinogen Induction of rat mammary tumors and the expression of an endogenous retrovlral genome was Initiated. Mammary tumors were Induced In female SO rats with 7,12-dimethylbenz[a]anthracene (OMBA). Tumors, Identified histologically as mammary adenocarcinomas, were analyzed for RNA of a replication-defective endogenous retrovirus or RNA of a helper-independent endogenous type C virus. Expression of RNA of the replication-defective virus was detected In mammary tumors weighing 0.2–2.0 g. Larger tumors, for which histologic examination revealed proportionally more fibroblastic tissue than epithelial cells, did not contain comparable concentrations of this viral RNA. RNA homologous to a helper-independent rat type C retrovirus was not detected in tumors of any size. A cell line was established from a primary OMBA-induced mammary adenocarcinoma and appeared similar to the small mammary tumors with respect to endogenous type C viral RNA expression. We discuss possible implications of the expression of endogenous replication- defective viruses for use as markers for the effects of chemical carcinogens.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/61.5.1329</identifier><identifier>PMID: 213614</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>9,10-Dimethyl-1,2-benzanthracene ; Adenocarcinoma - chemically induced ; Adenocarcinoma - metabolism ; Adenocarcinoma - microbiology ; Animals ; Benz(a)Anthracenes ; Cell Line ; Defective Viruses - metabolism ; Female ; Mammary Neoplasms, Experimental - chemically induced ; Mammary Neoplasms, Experimental - metabolism ; Mammary Neoplasms, Experimental - microbiology ; Neoplasms, Experimental - microbiology ; Nucleic Acid Hybridization ; Rats ; Retroviridae - metabolism ; RNA, Viral - biosynthesis ; Uterine Neoplasms - microbiology ; Virus Replication</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1978-11, Vol.61 (5), p.1329-1337</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/213614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Young, Howard A.</creatorcontrib><creatorcontrib>Wenk, Martin L.</creatorcontrib><creatorcontrib>Goodman, Dawn G.</creatorcontrib><creatorcontrib>Scolnick, Edward M.</creatorcontrib><title>Expression of RNA of an Endogenous Replication-Defective Retrovirus in Rat Mammary Adenocarcinomas Induced by 7,12-Dimethylbenz[a]anthracene</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>An investigation into the possible relationship between chemical carcinogen Induction of rat mammary tumors and the expression of an endogenous retrovlral genome was Initiated. Mammary tumors were Induced In female SO rats with 7,12-dimethylbenz[a]anthracene (OMBA). Tumors, Identified histologically as mammary adenocarcinomas, were analyzed for RNA of a replication-defective endogenous retrovirus or RNA of a helper-independent endogenous type C virus. Expression of RNA of the replication-defective virus was detected In mammary tumors weighing 0.2–2.0 g. Larger tumors, for which histologic examination revealed proportionally more fibroblastic tissue than epithelial cells, did not contain comparable concentrations of this viral RNA. RNA homologous to a helper-independent rat type C retrovirus was not detected in tumors of any size. A cell line was established from a primary OMBA-induced mammary adenocarcinoma and appeared similar to the small mammary tumors with respect to endogenous type C viral RNA expression. We discuss possible implications of the expression of endogenous replication- defective viruses for use as markers for the effects of chemical carcinogens.</description><subject>9,10-Dimethyl-1,2-benzanthracene</subject><subject>Adenocarcinoma - chemically induced</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - microbiology</subject><subject>Animals</subject><subject>Benz(a)Anthracenes</subject><subject>Cell Line</subject><subject>Defective Viruses - metabolism</subject><subject>Female</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Mammary Neoplasms, Experimental - microbiology</subject><subject>Neoplasms, Experimental - microbiology</subject><subject>Nucleic Acid Hybridization</subject><subject>Rats</subject><subject>Retroviridae - metabolism</subject><subject>RNA, Viral - biosynthesis</subject><subject>Uterine Neoplasms - microbiology</subject><subject>Virus Replication</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS3Eqzy2rFj4A0jxK3ayrGgLFQWkAhICochxxtSlcaI4RZRv4KMJKmI2V5pz79VoEDqhpE9Jys8X3rhzSftxn3KWbqEeFZJEjJJ4G_UIYSpKEiX20UEIC9JNysQe2mWUSyp66Hv0WTcQgqs8riye3Q5-RXs88kX1Br5aBTyDeumMbjtPNAQLpnUf0G3bpvpwTWdwHs90i290WepmjQdFlzO6Mc5XpQ544ouVgQLna6zOKIuGroR2vl7m4L9e9Kv27bzRBjwcoR2rlwGO__QQPY5HDxdX0fTucnIxmEaOCd5GSuUiTQtpLVdJTK1lliWWGBkzlYqUGmqVSQopTMyIEJAn1oABKmWcshwIP0Snm956lZdQZHXjfg_PNk_pcLTBLrTw-U91855JxVWcXT09Z-PhpSKcXmf3_AekMXTO</recordid><startdate>197811</startdate><enddate>197811</enddate><creator>Young, Howard A.</creator><creator>Wenk, Martin L.</creator><creator>Goodman, Dawn G.</creator><creator>Scolnick, Edward M.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197811</creationdate><title>Expression of RNA of an Endogenous Replication-Defective Retrovirus in Rat Mammary Adenocarcinomas Induced by 7,12-Dimethylbenz[a]anthracene</title><author>Young, Howard A. ; Wenk, Martin L. ; Goodman, Dawn G. ; Scolnick, Edward M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i243t-77b499d6ff37851ff2f28f0c65279491c1f7c8d64c52044eb8fcece166592be03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene</topic><topic>Adenocarcinoma - chemically induced</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - microbiology</topic><topic>Animals</topic><topic>Benz(a)Anthracenes</topic><topic>Cell Line</topic><topic>Defective Viruses - metabolism</topic><topic>Female</topic><topic>Mammary Neoplasms, Experimental - chemically induced</topic><topic>Mammary Neoplasms, Experimental - metabolism</topic><topic>Mammary Neoplasms, Experimental - microbiology</topic><topic>Neoplasms, Experimental - microbiology</topic><topic>Nucleic Acid Hybridization</topic><topic>Rats</topic><topic>Retroviridae - metabolism</topic><topic>RNA, Viral - biosynthesis</topic><topic>Uterine Neoplasms - microbiology</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Young, Howard A.</creatorcontrib><creatorcontrib>Wenk, Martin L.</creatorcontrib><creatorcontrib>Goodman, Dawn G.</creatorcontrib><creatorcontrib>Scolnick, Edward M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Young, Howard A.</au><au>Wenk, Martin L.</au><au>Goodman, Dawn G.</au><au>Scolnick, Edward M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of RNA of an Endogenous Replication-Defective Retrovirus in Rat Mammary Adenocarcinomas Induced by 7,12-Dimethylbenz[a]anthracene</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1978-11</date><risdate>1978</risdate><volume>61</volume><issue>5</issue><spage>1329</spage><epage>1337</epage><pages>1329-1337</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>An investigation into the possible relationship between chemical carcinogen Induction of rat mammary tumors and the expression of an endogenous retrovlral genome was Initiated. Mammary tumors were Induced In female SO rats with 7,12-dimethylbenz[a]anthracene (OMBA). Tumors, Identified histologically as mammary adenocarcinomas, were analyzed for RNA of a replication-defective endogenous retrovirus or RNA of a helper-independent endogenous type C virus. Expression of RNA of the replication-defective virus was detected In mammary tumors weighing 0.2–2.0 g. Larger tumors, for which histologic examination revealed proportionally more fibroblastic tissue than epithelial cells, did not contain comparable concentrations of this viral RNA. RNA homologous to a helper-independent rat type C retrovirus was not detected in tumors of any size. A cell line was established from a primary OMBA-induced mammary adenocarcinoma and appeared similar to the small mammary tumors with respect to endogenous type C viral RNA expression. We discuss possible implications of the expression of endogenous replication- defective viruses for use as markers for the effects of chemical carcinogens.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>213614</pmid><doi>10.1093/jnci/61.5.1329</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1978-11, Vol.61 (5), p.1329-1337 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_pubmed_primary_213614 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | 9,10-Dimethyl-1,2-benzanthracene Adenocarcinoma - chemically induced Adenocarcinoma - metabolism Adenocarcinoma - microbiology Animals Benz(a)Anthracenes Cell Line Defective Viruses - metabolism Female Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - microbiology Neoplasms, Experimental - microbiology Nucleic Acid Hybridization Rats Retroviridae - metabolism RNA, Viral - biosynthesis Uterine Neoplasms - microbiology Virus Replication |
| title | Expression of RNA of an Endogenous Replication-Defective Retrovirus in Rat Mammary Adenocarcinomas Induced by 7,12-Dimethylbenz[a]anthracene |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T00%3A33%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-istex_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20RNA%20of%20an%20Endogenous%20Replication-Defective%20Retrovirus%20in%20Rat%20Mammary%20Adenocarcinomas%20Induced%20by%207,12-Dimethylbenz%5Ba%5Danthracene&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=Young,%20Howard%20A.&rft.date=1978-11&rft.volume=61&rft.issue=5&rft.spage=1329&rft.epage=1337&rft.pages=1329-1337&rft.issn=0027-8874&rft.eissn=1460-2105&rft_id=info:doi/10.1093/jnci/61.5.1329&rft_dat=%3Cistex_pubme%3Eark_67375_HXZ_FDG7031K_S%3C/istex_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/213614&rfr_iscdi=true |