Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

Bevacizumab, an antibody against vascular endothelial growth factor (VEGF), is a promising, yet controversial, drug in human glioblastoma treatment (GBM). Its effects on tumor burden, recurrence, and vascular physiology are unclear. We therefore determined the tumor response to bevacizumab at the ph...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-03, Vol.108 (9), p.3749-3754
Hauptverfasser:	Keunen, Olivier, Johansson, Mikael, Oudin, Anaïs, Sanzey, Morgane, Rahim, Siti A. Abdul, Fack, Fred, Thorsen, Frits, Taxt, Torfinn, Bartos, Michal, Jirik, Radovan, Miletic, Hrvoje, Wang, Jian, Stieber, Daniel, Stuhr, Linda, Moen, Ingrid, Rygh, Cecilie Brekke, Bjerkvig, Rolf, Niclou, Simone P., Klein, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine angiogenesis Animals Antibodies Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Bevacizumab Biological Sciences Blood flow Blood vessels Blood Volume - drug effects Brain Cancer Capillary Permeability - drug effects Cell Hypoxia - drug effects Cells Cellular metabolism Contrast Media Disease Progression Drugs Enzyme Activation - drug effects Genotype & phenotype Glioblastoma Glioblastoma - blood supply Glioblastoma - enzymology Glioblastoma - pathology Glioblastoma - ultrastructure Glioma Glycolysis Heterologous transplantation Humans Hypoxia Hypoxia-inducible factor 1 alpha Lactic acid Magnetic Resonance Imaging Medical treatment Metabolic pathways metabolism Metabolites Mitochondria Neoplasm Invasiveness Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology NMR Nuclear magnetic resonance Perfusion Phosphatidylinositol 3-Kinases - metabolism Physiology Quantification Rats Rats, Nude Signal transduction Signal Transduction - drug effects spheroids Tumor cells Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Wnt Proteins - metabolism Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!