Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease

Amyloid-β (Aβ) peptide-binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, exacerbates Aβ-induced cell stress. The interaction of ABAD with Aβ exacerbates Aβ-induced mitochondrial and neuronal dysfunction. Here, we show that inhibition of the ABAD-Aβ interaction, using...

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Veröffentlicht in:	The Journal of neuroscience 2011-02, Vol.31 (6), p.2313
Hauptverfasser:	Yao, Jun, Du, Heng, Yan, Shiqiang, Fang, Fang, Wang, Chaodong, Lue, Lih-Fen, Guo, Lan, Chen, Doris, Stern, David M, Gunn Moore, Frank J, Xi Chen, John, Arancio, Ottavio, Yan, Shirley ShiDu
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxyacyl CoA Dehydrogenases - antagonists & inhibitors 3-Hydroxyacyl CoA Dehydrogenases - pharmacology 3-Hydroxyacyl CoA Dehydrogenases - therapeutic use Acetylcholinesterase - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - pharmacology Amyloid beta-Protein Precursor - genetics Animals Binding Sites - genetics Brain - metabolism Brain - pathology Brain - ultrastructure Disease Models, Animal Electron Transport Complex III - metabolism Electron Transport Complex IV - metabolism Enzyme-Linked Immunosorbent Assay Gene Expression Regulation - drug effects Gene Expression Regulation - physiology GPI-Linked Proteins - metabolism Humans Immunoprecipitation - methods Memory - drug effects Memory - physiology Mice Mice, Transgenic Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism Mutation - genetics Reactive Oxygen Species - metabolism Space Perception - drug effects Space Perception - physiology
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