Monosialoganglioside effects following cerebral ischemia: relationship with anti-neuronotoxic and pro-neuronotrophic effects

Increasing evidence is available indicating that systemically administered GM1 is able to provide for functional recovery in different experimental models of CNS injury, including cerebral ischemia. Current evidence indicates that the GM1 effects are associated, in the acute phase, with attenuation...

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Veröffentlicht in:	Acta neurobiologiae experimentalis 1990, Vol.50 (4-5), p.489
Hauptverfasser:	Lipartiti, M, Seren, M S, Lazzaro, A, Koga, T, Mazzari, S, Facci, L, Fusco, M, Toffano, G, Leon, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - drug therapy Brain Ischemia - physiopathology G(M1) Ganglioside - pharmacology G(M1) Ganglioside - therapeutic use Humans Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - physiopathology Neurons - drug effects Neurons - pathology Neurons - physiology
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container_title	Acta neurobiologiae experimentalis
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creator	Lipartiti, M Seren, M S Lazzaro, A Koga, T Mazzari, S Facci, L Fusco, M Toffano, G Leon, A
description	Increasing evidence is available indicating that systemically administered GM1 is able to provide for functional recovery in different experimental models of CNS injury, including cerebral ischemia. Current evidence indicates that the GM1 effects are associated, in the acute phase, with attenuation of secondary neuronal damage due to its capability to antagonize excitatory amino acid-related neurotoxicity in vivo as in vitro. Furthermore, the ganglioside is able to facilitate occurrence of long-term reparative processes, an effect most likely reflecting the potentiation of the action of neuronotrophic factors. This bifaceted action of GM1 makes the ganglioside ideally suited for clinical treatment of patients afflicted by cerebrovascular insufficiencies.
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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Animals Brain Ischemia - drug therapy Brain Ischemia - physiopathology G(M1) Ganglioside - pharmacology G(M1) Ganglioside - therapeutic use Humans Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - physiopathology Neurons - drug effects Neurons - pathology Neurons - physiology
title	Monosialoganglioside effects following cerebral ischemia: relationship with anti-neuronotoxic and pro-neuronotrophic effects
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