Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration

Increased intraabdominal (visceral) fat is associated with a high risk of diabetes and metabolic syndrome. We have previously shown that the mesodermal developmental transcription factor Tbx15 is highly differentially expressed between visceral and subcutaneous (s.c.) fat in both humans and rodents,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (7), p.2771-2776
Hauptverfasser:	Gesta, Stephane, Bezy, Olivier, Mori, Marcelo A, Macotela, Yazmin, Lee, Kevin Y, Kahn, C. Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adenosine triphosphatase Adenosine Triphosphate - metabolism Adipocytes Adipocytes - physiology Adipose tissues Animals ATP Azo Compounds Biological Sciences Cell Differentiation - drug effects Cell Differentiation - genetics Cell Differentiation - physiology Cell Respiration - genetics Cell Respiration - physiology Cells Cloning, Molecular Developmental genes Diabetes Diabetes mellitus Differentiation DNA Primers - genetics Electron transport Energy Metabolism - physiology Fatty acids Gene expression Genes Health risks Male Messenger RNA Metabolic disorders Metabolic syndrome Mice Mice, Inbred C57BL Mitochondria Mitochondria - physiology Obesity Oxygen Consumption - physiology Peroxisome proliferator-activated receptors Polymerase Chain Reaction PPAR gamma - agonists Preadipocytes Respiration Risk factors Rodents rosiglitazone Subcutaneous Fat - metabolism T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Thiazolidinediones - pharmacology Transcription factors Triglycerides Visceral fat White adipose tissue
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