Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2011-05, Vol.55 (5), p.1982-1989 |
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| container_end_page | 1989 |
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| container_issue | 5 |
| container_start_page | 1982 |
| container_title | Antimicrobial Agents and Chemotherapy |
| container_volume | 55 |
| creator | SHIBATA, Sayaka GILLESPIE, J. Robert MERRITT, Ethan A HOL, Wim G. J VERLINDE, Christophe L. M. J ERKANG FAN BUCKNER, Frederick S KELLEY, Angela M NAPULI, Alberto J ZHONGSHENG ZHANG KOVZUN, Kuzma V PEFLEY, Ranae M LAM, Jocelyn ZUCKER, Frank H VAN VOORHIS, Wesley C |
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| doi_str_mv | 10.1128/AAC.01796-10 |
| format | Article |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01796-10</identifier><identifier>PMID: 21282428</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>African trypanosomiasis ; Aminoacyl-tRNA ligase ; Animal models ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Blotting, Northern ; Cell culture ; Cell Proliferation - drug effects ; Cell survival ; Diamines - pharmacology ; Drugs ; Enzymes ; Experimental Therapeutics ; Homology ; Infection ; Mammalian cells ; Medical sciences ; Methionine-tRNA Ligase ; Methionine-tRNA Ligase - antagonists & inhibitors ; Mice ; Mice, Inbred BALB C ; Mortality ; Parasites ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Protein biosynthesis ; Public health ; RNA Interference ; RNA-mediated interference ; Toxicity ; Trypanocidal Agents - therapeutic use ; Trypanosoma brucei ; Trypanosoma brucei brucei ; Trypanosoma brucei brucei - drug effects ; Trypanosoma brucei brucei - enzymology</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.1982-1989</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011, American Society for Microbiology.</rights><rights>Copyright © 2011, American Society for Microbiology. 2011 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a505t-5743397205110c27805339e119598234979bc55e86fda7cff44fcda786f5616f3</citedby><cites>FETCH-LOGICAL-a505t-5743397205110c27805339e119598234979bc55e86fda7cff44fcda786f5616f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088252/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088252/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24141820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21282428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIBATA, Sayaka</creatorcontrib><creatorcontrib>GILLESPIE, J. Robert</creatorcontrib><creatorcontrib>MERRITT, Ethan A</creatorcontrib><creatorcontrib>HOL, Wim G. J</creatorcontrib><creatorcontrib>VERLINDE, Christophe L. M. J</creatorcontrib><creatorcontrib>ERKANG FAN</creatorcontrib><creatorcontrib>BUCKNER, Frederick S</creatorcontrib><creatorcontrib>KELLEY, Angela M</creatorcontrib><creatorcontrib>NAPULI, Alberto J</creatorcontrib><creatorcontrib>ZHONGSHENG ZHANG</creatorcontrib><creatorcontrib>KOVZUN, Kuzma V</creatorcontrib><creatorcontrib>PEFLEY, Ranae M</creatorcontrib><creatorcontrib>LAM, Jocelyn</creatorcontrib><creatorcontrib>ZUCKER, Frank H</creatorcontrib><creatorcontrib>VAN VOORHIS, Wesley C</creatorcontrib><title>Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>African trypanosomiasis</subject><subject>Aminoacyl-tRNA ligase</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell culture</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell survival</subject><subject>Diamines - pharmacology</subject><subject>Drugs</subject><subject>Enzymes</subject><subject>Experimental Therapeutics</subject><subject>Homology</subject><subject>Infection</subject><subject>Mammalian cells</subject><subject>Medical sciences</subject><subject>Methionine-tRNA Ligase</subject><subject>Methionine-tRNA Ligase - antagonists & inhibitors</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mortality</subject><subject>Parasites</subject><subject>Pharmacology. 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Robert</creator><creator>MERRITT, Ethan A</creator><creator>HOL, Wim G. J</creator><creator>VERLINDE, Christophe L. M. 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J ; VERLINDE, Christophe L. M. J ; ERKANG FAN ; BUCKNER, Frederick S ; KELLEY, Angela M ; NAPULI, Alberto J ; ZHONGSHENG ZHANG ; KOVZUN, Kuzma V ; PEFLEY, Ranae M ; LAM, Jocelyn ; ZUCKER, Frank H ; VAN VOORHIS, Wesley C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a505t-5743397205110c27805339e119598234979bc55e86fda7cff44fcda786f5616f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>African trypanosomiasis</topic><topic>Aminoacyl-tRNA ligase</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cell culture</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell survival</topic><topic>Diamines - pharmacology</topic><topic>Drugs</topic><topic>Enzymes</topic><topic>Experimental Therapeutics</topic><topic>Homology</topic><topic>Infection</topic><topic>Mammalian cells</topic><topic>Medical sciences</topic><topic>Methionine-tRNA Ligase</topic><topic>Methionine-tRNA Ligase - antagonists & inhibitors</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mortality</topic><topic>Parasites</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Protein biosynthesis</topic><topic>Public health</topic><topic>RNA Interference</topic><topic>RNA-mediated interference</topic><topic>Toxicity</topic><topic>Trypanocidal Agents - therapeutic use</topic><topic>Trypanosoma brucei</topic><topic>Trypanosoma brucei brucei</topic><topic>Trypanosoma brucei brucei - drug effects</topic><topic>Trypanosoma brucei brucei - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIBATA, Sayaka</creatorcontrib><creatorcontrib>GILLESPIE, J. Robert</creatorcontrib><creatorcontrib>MERRITT, Ethan A</creatorcontrib><creatorcontrib>HOL, Wim G. J</creatorcontrib><creatorcontrib>VERLINDE, Christophe L. M. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>21282428</pmid><doi>10.1128/AAC.01796-10</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.1982-1989 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_pubmed_primary_21282428 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | African trypanosomiasis Aminoacyl-tRNA ligase Animal models Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blotting, Northern Cell culture Cell Proliferation - drug effects Cell survival Diamines - pharmacology Drugs Enzymes Experimental Therapeutics Homology Infection Mammalian cells Medical sciences Methionine-tRNA Ligase Methionine-tRNA Ligase - antagonists & inhibitors Mice Mice, Inbred BALB C Mortality Parasites Pharmacology. Drug treatments Polymerase Chain Reaction Protein biosynthesis Public health RNA Interference RNA-mediated interference Toxicity Trypanocidal Agents - therapeutic use Trypanosoma brucei Trypanosoma brucei brucei Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - enzymology |
| title | Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice |
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