Mitochondria removal by autophagy
Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis. Several strategies have evolved to prevent and limit mitochondria damage, and macroa...
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| Veröffentlicht in: | Autophagy 2011-03, Vol.7 (3), p.297-300 |
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| container_title | Autophagy |
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| creator | Wang, Ke Klionsky, Daniel J |
| description | Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis. Several strategies have evolved to prevent and limit mitochondria damage, and macroautophagy plays a role in degrading superfluous or severely damaged mitochondria. Selective removal of mitochondria by autophagy (termed mitophagy) has been extensively studied recently in both yeast and mammalian cells. In this review, we summarize our current knowledge of mitophagy. We also compare the molecular process of mitophagy with other types of specific autophagic pathways and discuss its biological importance. |
| doi_str_mv | 10.4161/auto.7.3.14502 |
| format | Article |
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| ispartof | Autophagy, 2011-03, Vol.7 (3), p.297-300 |
| issn | 1554-8627 1554-8635 |
| language | eng |
| recordid | cdi_pubmed_primary_21252623 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino Acid Sequence Animals Autophagy Binding Biology Bioscience Calcium Cancer Cell Cycle Humans Landes Mitochondria - metabolism Mitochondrial Proteins - chemistry Mitochondrial Proteins - metabolism Models, Biological Molecular Sequence Data Organogenesis Proteins Review |
| title | Mitochondria removal by autophagy |
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