Validation of isoleucine utilization targets in Plasmodium falciparum

Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine, which is not present in adult human hemoglobin and must be obtained exogenously. We evaluated two compounds for their potential to interfere...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-01, Vol.108 (4), p.1627-1632
Hauptverfasser:	Istvan, Eva S., Dharia, Neekesh V., Bopp, Selina E., Gluzman, Ilya, Winzeler, Elizabeth A., Goldberg, Daniel E., Wellems, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino acids Animals Anti-Bacterial Agents - pharmacology Antibiotics Antimalarials Apicoplasts Biological Sciences Cytoplasm Dose-Response Relationship, Drug Drug resistance Drug Resistance - genetics Enzymes Erythrocytes - parasitology Fluorescence Genetic mutation Genome, Protozoan - genetics Genomes Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Hemoglobin Hemoglobins - metabolism Humans Isoleucine - analogs & derivatives Isoleucine - metabolism Isoleucine - pharmacology Isoleucine-tRNA Ligase - genetics Isoleucine-tRNA Ligase - metabolism Malaria Microscopy, Fluorescence Mupirocin - pharmacology Mutation Parasites Parasitic protozoa Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - metabolism Polymorphism, Single Nucleotide Protozoan Proteins - genetics Protozoan Proteins - metabolism Starvation Tiling
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