Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

Immunization of mice with a 14-mer peptide TKDNNLLGRFELSG, termed "TKD," comprising amino acids 450–461 (aa 450–461 ) in the C terminus of inducible Hsp70, resulted in the generation of an IgG1 mouse mAb cmHsp70.1. The epitope recognized by cmHsp70.1 mAb, which has been confirmed to be loc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-01, Vol.108 (2), p.733-738
Hauptverfasser:	Stangl, Stefan, Gehrmann, Mathias, Riegger, Julia, Kuhs, Kristin, Riederer, Isabelle, Sievert, Wolfgang, Hube, Kathrin, Mocikat, Ralph, Dressel, Ralf, Kremmer, Elisabeth, Pockley, Alan G., Friedrich, Lars, Vigh, Laszlo, Skerra, Arne, Multhoff, Gabriele, Kondorosi, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies Antibodies, Monoclonal - chemistry Antibody dependent cell cytotoxicity Binding sites Biochemistry Biological Sciences Cell Line, Tumor Cell lines Cell membranes Cholesterol - chemistry Cytotoxicity Granulocytes - cytology Heat shock proteins HSP70 Heat-Shock Proteins - chemistry Human subjects Humans Immunization Interleukin-2 - metabolism Killer Cells, Natural - cytology Macrophages - cytology Macrophages - metabolism Membranes Mice Mice, Inbred BALB C Mice, Inbred C57BL Natural killer cells Neoplasm Transplantation Peptides Protein Binding Protein Structure, Tertiary Rodents Spleen cells T lymphocytes Tumor cell line Tumors
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