Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3
The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. We show here that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3(+) regulatory T cells (T(reg) cells). We identify two...
Gespeichert in:
| Veröffentlicht in: | Nature immunology 2011-01, Vol.12 (1), p.86 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 86 |
| container_title | Nature immunology |
| container_volume | 12 |
| creator | Maruyama, Takashi Li, Jun Vaque, Jose P Konkel, Joanne E Wang, Weifeng Zhang, Baojun Zhang, Pin Zamarron, Brian F Yu, Dongyang Wu, Yuntao Zhuang, Yuan Gutkind, J Silvio Chen, WanJun |
| description | The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. We show here that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3(+) regulatory T cells (T(reg) cells). We identify two transforming growth factor-β1 (TGF-β1)-dependent mechanisms that were vital for activation of Foxp3 transcription and were defective in Id3(-/-) CD4(+) T cells. Enhanced binding of the transcription factor E2A to the Foxp3 promoter promoted Foxp3 transcription. Id3 was required for relief of inhibition by the transcription factor GATA-3 at the Foxp3 promoter. Furthermore, Id3(-/-) T cells showed greater differentiation into the T(H)17 subset of helper T cells in vitro and in a mouse asthma model. Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells. |
| doi_str_mv | 10.1038/ni.1965 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_21131965</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21131965</sourcerecordid><originalsourceid>FETCH-LOGICAL-p140t-886fcc2e06e09a00af3221599226207178655416832188ad026e4f770e2f34b33</originalsourceid><addsrcrecordid>eNo1j0tLAzEYRYMgtlbxH0iWupiaL8nksSzjo4Wim3FdMpOkjUwzJZMu5t9rta4uHO65cBG6AzIHwtRTDHPQorxAUyipLqgGMUHXw_BFCHAp-BWaUAB26kyRr_qYU9_h3uO8c9gG711yMQeTQx9POLntsTO5TyOuceu6bsAmWlw_LB9BnkEz_trP74uiCdGGuMUh7kITfjS8suwGXXrTDe72nDP0-fpSV8ti_fG2qhbr4gCc5EIp4duWOiIc0YYQ4xmlUGpNqaBEglSiLDkIxSgoZSyhwnEvJXHUM94wNkP3f7uHY7N3dnNIYW_SuPk_zL4Bmh1R2Q</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink Journals - AutoHoldings</source><creator>Maruyama, Takashi ; Li, Jun ; Vaque, Jose P ; Konkel, Joanne E ; Wang, Weifeng ; Zhang, Baojun ; Zhang, Pin ; Zamarron, Brian F ; Yu, Dongyang ; Wu, Yuntao ; Zhuang, Yuan ; Gutkind, J Silvio ; Chen, WanJun</creator><creatorcontrib>Maruyama, Takashi ; Li, Jun ; Vaque, Jose P ; Konkel, Joanne E ; Wang, Weifeng ; Zhang, Baojun ; Zhang, Pin ; Zamarron, Brian F ; Yu, Dongyang ; Wu, Yuntao ; Zhuang, Yuan ; Gutkind, J Silvio ; Chen, WanJun</creatorcontrib><description>The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. We show here that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3(+) regulatory T cells (T(reg) cells). We identify two transforming growth factor-β1 (TGF-β1)-dependent mechanisms that were vital for activation of Foxp3 transcription and were defective in Id3(-/-) CD4(+) T cells. Enhanced binding of the transcription factor E2A to the Foxp3 promoter promoted Foxp3 transcription. Id3 was required for relief of inhibition by the transcription factor GATA-3 at the Foxp3 promoter. Furthermore, Id3(-/-) T cells showed greater differentiation into the T(H)17 subset of helper T cells in vitro and in a mouse asthma model. Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells.</description><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni.1965</identifier><identifier>PMID: 21131965</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Asthma - chemically induced ; Asthma - genetics ; Asthma - immunology ; Asthma - metabolism ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Cell Differentiation - genetics ; Cells, Cultured ; Disease Models, Animal ; Forkhead Transcription Factors - genetics ; Forkhead Transcription Factors - metabolism ; Inhibitor of Differentiation Proteins - genetics ; Inhibitor of Differentiation Proteins - immunology ; Inhibitor of Differentiation Proteins - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Promoter Regions, Genetic - genetics ; Protein Binding - genetics ; Sequence Deletion - genetics ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - metabolism ; T-Lymphocytes, Regulatory - pathology ; Th17 Cells - immunology ; Th17 Cells - metabolism ; Th17 Cells - pathology ; Transcriptional Activation - genetics ; Transforming Growth Factor beta1 - metabolism</subject><ispartof>Nature immunology, 2011-01, Vol.12 (1), p.86</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21131965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maruyama, Takashi</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Vaque, Jose P</creatorcontrib><creatorcontrib>Konkel, Joanne E</creatorcontrib><creatorcontrib>Wang, Weifeng</creatorcontrib><creatorcontrib>Zhang, Baojun</creatorcontrib><creatorcontrib>Zhang, Pin</creatorcontrib><creatorcontrib>Zamarron, Brian F</creatorcontrib><creatorcontrib>Yu, Dongyang</creatorcontrib><creatorcontrib>Wu, Yuntao</creatorcontrib><creatorcontrib>Zhuang, Yuan</creatorcontrib><creatorcontrib>Gutkind, J Silvio</creatorcontrib><creatorcontrib>Chen, WanJun</creatorcontrib><title>Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><description>The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. We show here that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3(+) regulatory T cells (T(reg) cells). We identify two transforming growth factor-β1 (TGF-β1)-dependent mechanisms that were vital for activation of Foxp3 transcription and were defective in Id3(-/-) CD4(+) T cells. Enhanced binding of the transcription factor E2A to the Foxp3 promoter promoted Foxp3 transcription. Id3 was required for relief of inhibition by the transcription factor GATA-3 at the Foxp3 promoter. Furthermore, Id3(-/-) T cells showed greater differentiation into the T(H)17 subset of helper T cells in vitro and in a mouse asthma model. Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells.</description><subject>Animals</subject><subject>Asthma - chemically induced</subject><subject>Asthma - genetics</subject><subject>Asthma - immunology</subject><subject>Asthma - metabolism</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Cell Differentiation - genetics</subject><subject>Cells, Cultured</subject><subject>Disease Models, Animal</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Inhibitor of Differentiation Proteins - genetics</subject><subject>Inhibitor of Differentiation Proteins - immunology</subject><subject>Inhibitor of Differentiation Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Protein Binding - genetics</subject><subject>Sequence Deletion - genetics</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><subject>T-Lymphocytes, Regulatory - pathology</subject><subject>Th17 Cells - immunology</subject><subject>Th17 Cells - metabolism</subject><subject>Th17 Cells - pathology</subject><subject>Transcriptional Activation - genetics</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j0tLAzEYRYMgtlbxH0iWupiaL8nksSzjo4Wim3FdMpOkjUwzJZMu5t9rta4uHO65cBG6AzIHwtRTDHPQorxAUyipLqgGMUHXw_BFCHAp-BWaUAB26kyRr_qYU9_h3uO8c9gG711yMQeTQx9POLntsTO5TyOuceu6bsAmWlw_LB9BnkEz_trP74uiCdGGuMUh7kITfjS8suwGXXrTDe72nDP0-fpSV8ti_fG2qhbr4gCc5EIp4duWOiIc0YYQ4xmlUGpNqaBEglSiLDkIxSgoZSyhwnEvJXHUM94wNkP3f7uHY7N3dnNIYW_SuPk_zL4Bmh1R2Q</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Maruyama, Takashi</creator><creator>Li, Jun</creator><creator>Vaque, Jose P</creator><creator>Konkel, Joanne E</creator><creator>Wang, Weifeng</creator><creator>Zhang, Baojun</creator><creator>Zhang, Pin</creator><creator>Zamarron, Brian F</creator><creator>Yu, Dongyang</creator><creator>Wu, Yuntao</creator><creator>Zhuang, Yuan</creator><creator>Gutkind, J Silvio</creator><creator>Chen, WanJun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201101</creationdate><title>Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3</title><author>Maruyama, Takashi ; Li, Jun ; Vaque, Jose P ; Konkel, Joanne E ; Wang, Weifeng ; Zhang, Baojun ; Zhang, Pin ; Zamarron, Brian F ; Yu, Dongyang ; Wu, Yuntao ; Zhuang, Yuan ; Gutkind, J Silvio ; Chen, WanJun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-886fcc2e06e09a00af3221599226207178655416832188ad026e4f770e2f34b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Asthma - chemically induced</topic><topic>Asthma - genetics</topic><topic>Asthma - immunology</topic><topic>Asthma - metabolism</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Cell Differentiation - genetics</topic><topic>Cells, Cultured</topic><topic>Disease Models, Animal</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Inhibitor of Differentiation Proteins - genetics</topic><topic>Inhibitor of Differentiation Proteins - immunology</topic><topic>Inhibitor of Differentiation Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Protein Binding - genetics</topic><topic>Sequence Deletion - genetics</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - metabolism</topic><topic>T-Lymphocytes, Regulatory - pathology</topic><topic>Th17 Cells - immunology</topic><topic>Th17 Cells - metabolism</topic><topic>Th17 Cells - pathology</topic><topic>Transcriptional Activation - genetics</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maruyama, Takashi</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Vaque, Jose P</creatorcontrib><creatorcontrib>Konkel, Joanne E</creatorcontrib><creatorcontrib>Wang, Weifeng</creatorcontrib><creatorcontrib>Zhang, Baojun</creatorcontrib><creatorcontrib>Zhang, Pin</creatorcontrib><creatorcontrib>Zamarron, Brian F</creatorcontrib><creatorcontrib>Yu, Dongyang</creatorcontrib><creatorcontrib>Wu, Yuntao</creatorcontrib><creatorcontrib>Zhuang, Yuan</creatorcontrib><creatorcontrib>Gutkind, J Silvio</creatorcontrib><creatorcontrib>Chen, WanJun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maruyama, Takashi</au><au>Li, Jun</au><au>Vaque, Jose P</au><au>Konkel, Joanne E</au><au>Wang, Weifeng</au><au>Zhang, Baojun</au><au>Zhang, Pin</au><au>Zamarron, Brian F</au><au>Yu, Dongyang</au><au>Wu, Yuntao</au><au>Zhuang, Yuan</au><au>Gutkind, J Silvio</au><au>Chen, WanJun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3</atitle><jtitle>Nature immunology</jtitle><addtitle>Nat Immunol</addtitle><date>2011-01</date><risdate>2011</risdate><volume>12</volume><issue>1</issue><spage>86</spage><pages>86-</pages><eissn>1529-2916</eissn><abstract>The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. We show here that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3(+) regulatory T cells (T(reg) cells). We identify two transforming growth factor-β1 (TGF-β1)-dependent mechanisms that were vital for activation of Foxp3 transcription and were defective in Id3(-/-) CD4(+) T cells. Enhanced binding of the transcription factor E2A to the Foxp3 promoter promoted Foxp3 transcription. Id3 was required for relief of inhibition by the transcription factor GATA-3 at the Foxp3 promoter. Furthermore, Id3(-/-) T cells showed greater differentiation into the T(H)17 subset of helper T cells in vitro and in a mouse asthma model. Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells.</abstract><cop>United States</cop><pmid>21131965</pmid><doi>10.1038/ni.1965</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1529-2916 |
| ispartof | Nature immunology, 2011-01, Vol.12 (1), p.86 |
| issn | 1529-2916 |
| language | eng |
| recordid | cdi_pubmed_primary_21131965 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Animals Asthma - chemically induced Asthma - genetics Asthma - immunology Asthma - metabolism Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Differentiation - genetics Cells, Cultured Disease Models, Animal Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Inhibitor of Differentiation Proteins - genetics Inhibitor of Differentiation Proteins - immunology Inhibitor of Differentiation Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Promoter Regions, Genetic - genetics Protein Binding - genetics Sequence Deletion - genetics T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Th17 Cells - immunology Th17 Cells - metabolism Th17 Cells - pathology Transcriptional Activation - genetics Transforming Growth Factor beta1 - metabolism |
| title | Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T21%3A28%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Control%20of%20the%20differentiation%20of%20regulatory%20T%20cells%20and%20T(H)17%20cells%20by%20the%20DNA-binding%20inhibitor%20Id3&rft.jtitle=Nature%20immunology&rft.au=Maruyama,%20Takashi&rft.date=2011-01&rft.volume=12&rft.issue=1&rft.spage=86&rft.pages=86-&rft.eissn=1529-2916&rft_id=info:doi/10.1038/ni.1965&rft_dat=%3Cpubmed%3E21131965%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/21131965&rfr_iscdi=true |