Immune Modulation Exerted by Thymic Humoral Factor (Thf-γ2), on T-Cell Subsets and Il-2 Production of Umbilical Cord Blood Lymphocytes
Abstract The effect of a synthetic thymic humoral factor, THF-γ2, on the immune competence of T-cells was investigated in vitro on lymphocytes from human cord blood (UCBL). It was found that preincubation of UCBL with THF-γ2 caused an increase in the percentage of cells expressing the CD4 or the CD8...
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| Veröffentlicht in: | Immunopharmacology and immunotoxicology 1990, Vol.12 (1), p.123-133 |
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| container_title | Immunopharmacology and immunotoxicology |
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| creator | H, Ben-Hur M, Pecht L, Netzer R, Borenstein I, Blickstein Y, Burstein N, Trainin |
| description | Abstract
The effect of a synthetic thymic humoral factor, THF-γ2, on the immune competence of T-cells was investigated in vitro on lymphocytes from human cord blood (UCBL). It was found that preincubation of UCBL with THF-γ2 caused an increase in the percentage of cells expressing the CD4 or the CD8 differentiation antigens, but did not affect the percentage of CD3 cells. The effect of THF-γ2 on PHA-induced IL-2 secretion was also studied and found that a 3hr preincubation with THF-γ2, prior to suboptimal PHA stimulation caused an increase in the IL-2 activity of the treated UCBL cultures. This effect was THF-γ2 dose dependent with an optimum in the range of 300-600 ng/ml and was not influenced by irradiation of the UCBL. These results indicate that THF-γ2, a synthetic octapeptide, modulates the immune state and response of human umbilical cord blood lymphocytes. |
| doi_str_mv | 10.3109/08923979009006465 |
| format | Article |
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The effect of a synthetic thymic humoral factor, THF-γ2, on the immune competence of T-cells was investigated in vitro on lymphocytes from human cord blood (UCBL). It was found that preincubation of UCBL with THF-γ2 caused an increase in the percentage of cells expressing the CD4 or the CD8 differentiation antigens, but did not affect the percentage of CD3 cells. The effect of THF-γ2 on PHA-induced IL-2 secretion was also studied and found that a 3hr preincubation with THF-γ2, prior to suboptimal PHA stimulation caused an increase in the IL-2 activity of the treated UCBL cultures. This effect was THF-γ2 dose dependent with an optimum in the range of 300-600 ng/ml and was not influenced by irradiation of the UCBL. These results indicate that THF-γ2, a synthetic octapeptide, modulates the immune state and response of human umbilical cord blood lymphocytes.</description><identifier>ISSN: 0892-3973</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.3109/08923979009006465</identifier><identifier>PMID: 2112568</identifier><identifier>CODEN: IITOEF</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Antigens, Differentiation, T-Lymphocyte ; Biological and medical sciences ; CD4 Antigens ; CD8 Antigens ; Fetal Blood - cytology ; Fetal Blood - immunology ; Humans ; Immunocompetence - drug effects ; Immunomodulators ; In Vitro Techniques ; Infant, Newborn ; Interleukin-2 - biosynthesis ; Lymphocytes - drug effects ; Lymphocytes - immunology ; Medical sciences ; Pharmacology. Drug treatments ; Phenotype ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; Thymus Hormones - pharmacology</subject><ispartof>Immunopharmacology and immunotoxicology, 1990, Vol.12 (1), p.123-133</ispartof><rights>1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-f5a0c41173705faba16488943e3aeb23a83b22db3b62aeb164eaf18e88e7506e3</citedby><cites>FETCH-LOGICAL-c431t-f5a0c41173705faba16488943e3aeb23a83b22db3b62aeb164eaf18e88e7506e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08923979009006465$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08923979009006465$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4014,27914,27915,27916,59636,59742,60425,60531,61210,61245,61391,61426</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19249615$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2112568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>H, Ben-Hur</creatorcontrib><creatorcontrib>M, Pecht</creatorcontrib><creatorcontrib>L, Netzer</creatorcontrib><creatorcontrib>R, Borenstein</creatorcontrib><creatorcontrib>I, Blickstein</creatorcontrib><creatorcontrib>Y, Burstein</creatorcontrib><creatorcontrib>N, Trainin</creatorcontrib><title>Immune Modulation Exerted by Thymic Humoral Factor (Thf-γ2), on T-Cell Subsets and Il-2 Production of Umbilical Cord Blood Lymphocytes</title><title>Immunopharmacology and immunotoxicology</title><addtitle>Immunopharmacol Immunotoxicol</addtitle><description>Abstract
The effect of a synthetic thymic humoral factor, THF-γ2, on the immune competence of T-cells was investigated in vitro on lymphocytes from human cord blood (UCBL). It was found that preincubation of UCBL with THF-γ2 caused an increase in the percentage of cells expressing the CD4 or the CD8 differentiation antigens, but did not affect the percentage of CD3 cells. The effect of THF-γ2 on PHA-induced IL-2 secretion was also studied and found that a 3hr preincubation with THF-γ2, prior to suboptimal PHA stimulation caused an increase in the IL-2 activity of the treated UCBL cultures. This effect was THF-γ2 dose dependent with an optimum in the range of 300-600 ng/ml and was not influenced by irradiation of the UCBL. These results indicate that THF-γ2, a synthetic octapeptide, modulates the immune state and response of human umbilical cord blood lymphocytes.</description><subject>Antigens, Differentiation, T-Lymphocyte</subject><subject>Biological and medical sciences</subject><subject>CD4 Antigens</subject><subject>CD8 Antigens</subject><subject>Fetal Blood - cytology</subject><subject>Fetal Blood - immunology</subject><subject>Humans</subject><subject>Immunocompetence - drug effects</subject><subject>Immunomodulators</subject><subject>In Vitro Techniques</subject><subject>Infant, Newborn</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>Thymus Hormones - pharmacology</subject><issn>0892-3973</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9qFDEYxYNY6lp9AC-E3CgtdDR_5i96U5fWLqwouL0evsl8YaYkkzWZQecJfCDfo89k1l0VEQqBQM45P3IOIc84eyU5q16zshKyKirG4snTPHtAFjyTIhEZlw_JYqcn0SAfkcch3DLGq4Jlx-RYcC6yvFyQ7ytrpwHpB9dOBsbeDfTyG_oRW9rMdNPNtlf0erLOg6FXoEbn6emm08ndD3F2TqN9kyzRGPp5agKOgcLQ0pVJBP3kI1L9IjpNb2zTm15FyNL5lr4zzrV0Pdtt59Q8YnhCjjSYgE8P9wm5ubrcLK-T9cf3q-XFOlGp5GOiM2Aq5byQsYeGBnielmWVSpSAjZBQykaItpFNLuJDVBE0L7EsschYjvKEvNxzt959mTCMte2DigVgQDeFuqjKuBHPo5Hvjcq7EDzqeut7C36uOat349f_jR8zzw_wqbHY_kkc1o76i4MOIU6hPQyqD3_BlUirnO84b_e-ftDOW_jqvGnrEWbj_O-QvO8bb_6Jdwhm7BR4rG_d5Ie47z0lfgIOvbGn</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>H, Ben-Hur</creator><creator>M, Pecht</creator><creator>L, Netzer</creator><creator>R, Borenstein</creator><creator>I, Blickstein</creator><creator>Y, Burstein</creator><creator>N, Trainin</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Immune Modulation Exerted by Thymic Humoral Factor (Thf-γ2), on T-Cell Subsets and Il-2 Production of Umbilical Cord Blood Lymphocytes</title><author>H, Ben-Hur ; M, Pecht ; L, Netzer ; R, Borenstein ; I, Blickstein ; Y, Burstein ; N, Trainin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-f5a0c41173705faba16488943e3aeb23a83b22db3b62aeb164eaf18e88e7506e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Antigens, Differentiation, T-Lymphocyte</topic><topic>Biological and medical sciences</topic><topic>CD4 Antigens</topic><topic>CD8 Antigens</topic><topic>Fetal Blood - cytology</topic><topic>Fetal Blood - immunology</topic><topic>Humans</topic><topic>Immunocompetence - drug effects</topic><topic>Immunomodulators</topic><topic>In Vitro Techniques</topic><topic>Infant, Newborn</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - immunology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>Thymus Hormones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>H, Ben-Hur</creatorcontrib><creatorcontrib>M, Pecht</creatorcontrib><creatorcontrib>L, Netzer</creatorcontrib><creatorcontrib>R, Borenstein</creatorcontrib><creatorcontrib>I, Blickstein</creatorcontrib><creatorcontrib>Y, Burstein</creatorcontrib><creatorcontrib>N, Trainin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunopharmacology and immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>H, Ben-Hur</au><au>M, Pecht</au><au>L, Netzer</au><au>R, Borenstein</au><au>I, Blickstein</au><au>Y, Burstein</au><au>N, Trainin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune Modulation Exerted by Thymic Humoral Factor (Thf-γ2), on T-Cell Subsets and Il-2 Production of Umbilical Cord Blood Lymphocytes</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>Immunopharmacol Immunotoxicol</addtitle><date>1990</date><risdate>1990</risdate><volume>12</volume><issue>1</issue><spage>123</spage><epage>133</epage><pages>123-133</pages><issn>0892-3973</issn><eissn>1532-2513</eissn><coden>IITOEF</coden><abstract>Abstract
The effect of a synthetic thymic humoral factor, THF-γ2, on the immune competence of T-cells was investigated in vitro on lymphocytes from human cord blood (UCBL). It was found that preincubation of UCBL with THF-γ2 caused an increase in the percentage of cells expressing the CD4 or the CD8 differentiation antigens, but did not affect the percentage of CD3 cells. The effect of THF-γ2 on PHA-induced IL-2 secretion was also studied and found that a 3hr preincubation with THF-γ2, prior to suboptimal PHA stimulation caused an increase in the IL-2 activity of the treated UCBL cultures. This effect was THF-γ2 dose dependent with an optimum in the range of 300-600 ng/ml and was not influenced by irradiation of the UCBL. These results indicate that THF-γ2, a synthetic octapeptide, modulates the immune state and response of human umbilical cord blood lymphocytes.</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>2112568</pmid><doi>10.3109/08923979009006465</doi><tpages>11</tpages></addata></record> |
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| ispartof | Immunopharmacology and immunotoxicology, 1990, Vol.12 (1), p.123-133 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Antigens, Differentiation, T-Lymphocyte Biological and medical sciences CD4 Antigens CD8 Antigens Fetal Blood - cytology Fetal Blood - immunology Humans Immunocompetence - drug effects Immunomodulators In Vitro Techniques Infant, Newborn Interleukin-2 - biosynthesis Lymphocytes - drug effects Lymphocytes - immunology Medical sciences Pharmacology. Drug treatments Phenotype T-Lymphocytes - drug effects T-Lymphocytes - immunology Thymus Hormones - pharmacology |
| title | Immune Modulation Exerted by Thymic Humoral Factor (Thf-γ2), on T-Cell Subsets and Il-2 Production of Umbilical Cord Blood Lymphocytes |
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