Endothelial cells in pancreatic islet development and function
Endothelial cells represent one of the most abundant and widely found cell types in the mammalian embryo. These cells arise in close proximity with and often as an integral part of several organs such as the kidneys, lungs, liver and pancreas. In most of these organs, they play an instructive role t...
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| Veröffentlicht in: | Islets 2009-07, Vol.1 (1), p.2-9 |
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| creator | Ranjan, Amaresh K Joglekar, Mugdha V. Hardikar, Anandwardhan |
| description | Endothelial cells represent one of the most abundant and widely found cell types in the mammalian embryo. These cells arise in close proximity with and often as an integral part of several organs such as the kidneys, lungs, liver and pancreas. In most of these organs, they play an instructive role to determine the fate of progenitor cells in the developing embryo. Studies carried out until now by Eckhard Lammert, Douglas Melton, Ken Zaret and colleagues have convincingly demonstrated the importance of endothelial cells in normal development of the pancreas. This article reviews the literature in development of endothelial and endodermal cells. Understanding these endothelium-derived signaling mechanisms that allow differentiation of endodermal cells to endocrine pancreatic lineage will help us develop strategies for making insulin-producing cells in vitro. |
| doi_str_mv | 10.4161/isl.1.1.9054 |
| format | Article |
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Understanding these endothelium-derived signaling mechanisms that allow differentiation of endodermal cells to endocrine pancreatic lineage will help us develop strategies for making insulin-producing cells in vitro.</description><subject>Animals</subject><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Bone Marrow Cells - physiology</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cell Differentiation</subject><subject>Cycle</subject><subject>Embryo, Mammalian</subject><subject>Endothelial Cells - physiology</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Humans</subject><subject>Islets of Langerhans - embryology</subject><subject>Islets of Langerhans - growth & development</subject><subject>Islets of Langerhans - metabolism</subject><subject>Islets of Langerhans - physiology</subject><subject>Landes</subject><subject>Mesoderm - cytology</subject><subject>Mesoderm - embryology</subject><subject>Models, Biological</subject><subject>Organogenesis</subject><subject>Proteins</subject><issn>1938-2014</issn><issn>1938-2022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNptkEtPAyEURonRWK3uXJvZubEVZmAeGxPT1EfSxI2uCQOXiGGgwoym_17qtF2Zu4DF4eO7B6ErgueUlOTORDsnaRrM6BE6I01Rz3Kc58eHO6ETdB7jJ8Zlk2N6iiY5wTWtaXGG7pdO-f4DrBE2k2BtzIzL1sLJAKI3Mkvx0GcKvsH6dQeuz4RTmR6c7I13F-hECxvhcndO0fvj8m3xPFu9Pr0sHlYzSeuynxHCWp2zupWsoZQp1eJKKForTHVJFaNKV7kmIlVSjJQFQE5bKlghqWwUkGKKbsbcdfBfA8SedyZu6woHfoi8TvuUhFQskbcjKYOPMYDm62A6ETacYL4VxtNGnKTZCkv49S54aDtQB3hvKAHFCKSvFMTW-CgNOAkH9M9Q5CIkXRb2sdX4yjjtQyd-fLCK92JjfdAh2TWRF_8W-gUWgo0M</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Ranjan, Amaresh K</creator><creator>Joglekar, Mugdha V.</creator><creator>Hardikar, Anandwardhan</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Endothelial cells in pancreatic islet development and function</title><author>Ranjan, Amaresh K ; Joglekar, Mugdha V. ; Hardikar, Anandwardhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-115bf258bc59445ddb07ad48d04f64d54df72f1a843d5163ee24b4a53c4c9de13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Bone Marrow Cells - physiology</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cell Differentiation</topic><topic>Cycle</topic><topic>Embryo, Mammalian</topic><topic>Endothelial Cells - physiology</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Humans</topic><topic>Islets of Langerhans - embryology</topic><topic>Islets of Langerhans - growth & development</topic><topic>Islets of Langerhans - metabolism</topic><topic>Islets of Langerhans - physiology</topic><topic>Landes</topic><topic>Mesoderm - cytology</topic><topic>Mesoderm - embryology</topic><topic>Models, Biological</topic><topic>Organogenesis</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ranjan, Amaresh K</creatorcontrib><creatorcontrib>Joglekar, Mugdha V.</creatorcontrib><creatorcontrib>Hardikar, Anandwardhan</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Islets</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ranjan, Amaresh K</au><au>Joglekar, Mugdha V.</au><au>Hardikar, Anandwardhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial cells in pancreatic islet development and function</atitle><jtitle>Islets</jtitle><addtitle>Islets</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>1</volume><issue>1</issue><spage>2</spage><epage>9</epage><pages>2-9</pages><issn>1938-2014</issn><eissn>1938-2022</eissn><abstract>Endothelial cells represent one of the most abundant and widely found cell types in the mammalian embryo. 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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Binding Biology Bioscience Bone Marrow Cells - physiology Calcium Cancer Cell Cell Differentiation Cycle Embryo, Mammalian Endothelial Cells - physiology Hematopoietic Stem Cells - physiology Humans Islets of Langerhans - embryology Islets of Langerhans - growth & development Islets of Langerhans - metabolism Islets of Langerhans - physiology Landes Mesoderm - cytology Mesoderm - embryology Models, Biological Organogenesis Proteins |
| title | Endothelial cells in pancreatic islet development and function |
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