MyD88 Deficiency Leads to Decreased NK Cell Gamma Interferon Production and T Cell Recruitment during Chlamydia muridarum Genital Tract Infection, but a Predominant Th1 Response and Enhanced Monocytic Inflammation Are Associated with Infection Resolution

We have previously shown that MyD88 knockout (KO) mice exhibit delayed clearance of Chlamydia muridarum genital infection compared to wild-type (WT) mice. A blunted Th1 response and ineffective suppression of the Th2 response were also observed in MyD88 KO mice. The goal of the present study was to...

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Veröffentlicht in:	Infection and Immunity 2011-01, Vol.79 (1), p.486-498
Hauptverfasser:	Nagarajan, Uma M, Sikes, James, Prantner, Daniel, Andrews, Charles W. Jr, Frazer, Lauren, Goodwin, Anna, Snowden, Jessica N, Darville, Toni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences Chlamydia Infections - immunology Chlamydia Infections - microbiology Chlamydia Infections - pathology Chlamydia muridarum Fallopian Tubes - pathology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Host Response and Inflammation Inflammation - pathology Interferon-gamma - genetics Interferon-gamma - metabolism Interleukins - genetics Interleukins - metabolism Killer Cells, Natural - metabolism Mice Mice, Knockout Microbiology Monocytes - physiology Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains RNA, Messenger - genetics RNA, Messenger - metabolism T-Lymphocytes - physiology Th1 Cells - physiology Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Uterus - pathology Vaginitis - microbiology
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