Inhibition of Rho-Kinase Abrogates Migration of Human Transitional Cell Carcinoma Cells: Results of an in vitro Study

Introduction: Migration of cells involves a complex signaling network. The aim of the present study was to elucidate the impact of Rho-kinase (ROK) on G protein-coupled receptor-induced migration of human transitional cell carcinoma cells in an in vitro experimental setting. Materials and Methods: I...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Urologia internationalis 2011-01, Vol.86 (2), p.220-227
Hauptverfasser:	vom Dorp, Frank, Sanders, Harald, Boergermann, Christof, Lümmen, Gerd, Rübben, Herbert, Jakobs, Karl H., Schmidt, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Actins - chemistry Amides - pharmacology Bacterial Proteins - chemistry Bacterial Toxins - chemistry Calcium - chemistry Calcium - metabolism Carcinoma, Transitional Cell - enzymology Cell Line, Tumor Cell Movement Fura-2 - pharmacology Gene Expression Regulation, Neoplastic Humans In Vitro Techniques Lysophospholipids - chemistry Lysophospholipids - pharmacology Mutation Original Paper Pertussis Toxin - pharmacology Phalloidine - chemistry Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology rho GTP-Binding Proteins - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Type C Phospholipases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!