Structural Dissection and In Vivo Effectiveness of a Peptide Inhibitor of Porphyromonas gingivalis Adherence to Streptococcus gordonii

The interaction of the minor fimbrial antigen (Mfa) with streptococcal antigen I/II (e.g., SspB) facilitates colonization of the dental biofilm by Porphyromonas gingivalis. We previously showed that a 27-mer peptide derived from SspB (designated BAR) resembles the nuclear receptor (NR) box protein-p...

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Veröffentlicht in:	Infection and Immunity 2011-01, Vol.79 (1), p.67-74
Hauptverfasser:	Daep, Carlo Amorin, Novak, Elizabeth A, Lamont, Richard J, Demuth, Donald R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacterial Adhesion - drug effects Bacterial Infections Bacteriology Bacteroidaceae Infections - drug therapy Bacteroidaceae Infections - microbiology Biofilms - growth & development Biological and medical sciences Cells, Cultured Epithelial Cells - microbiology Fundamental and applied biological sciences. Psychology Gingiva - cytology Humans Mice Mice, Inbred BALB C Microbiology Miscellaneous Peptides - chemistry Peptides - therapeutic use Periodontitis - microbiology Periodontitis - prevention & control Porphyromonas gingivalis Porphyromonas gingivalis - drug effects Porphyromonas gingivalis - physiology Specific Pathogen-Free Organisms Streptococcal Infections - drug therapy Streptococcal Infections - microbiology Streptococcus gordonii Streptococcus gordonii - physiology
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