Formulation and dosage form design in drug-induced topical irritation of the gastrointestinal tract

To test drugs for topical effects on gastrointestinal mucosa, a new in situ rabbit colon model was used that permits direct application of drugs in suspensions from gel cups, solutions, or commercially available tablets and capsules onto rabbit colonic mucosa for up to 8 hr. For each agent tested an...

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Veröffentlicht in:	Pharmaceutical research 1990-06, Vol.7 (6), p.616-620
Hauptverfasser:	FARA, J. W, MYRBACK, R. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Capsules Chemistry, Pharmaceutical Colon - anatomy & histology Colon - drug effects Delayed-Action Preparations Drug Compounding Drug Design Drug toxicity and drugs side effects treatment Drug-Related Side Effects and Adverse Reactions Female Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - physiopathology Intestinal Mucosa - anatomy & histology Intestinal Mucosa - drug effects Irritants Male Medical sciences Pharmacology. Drug treatments Potassium Chloride - administration & dosage Potassium Chloride - adverse effects Rabbits Tablets Toxicity: digestive system
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