The Effect of PACAP38 on MyD88-Mediated Signal Transduction in Ischemia-/Hypoxia-Induced Acute Kidney Injury

Background/Aims: Toll-like receptor 4 (TLR4) and its adaptor protein MyD88 play an important role in ischemia/reperfusion (I/R) injury in the kidney, and pituitary adenylate cyclase-activating polypeptide (PACAP) could ameliorate renal I/R injury. Methods: Primary cultures of proximal tubule epithel...

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Veröffentlicht in:	American journal of nephrology 2010-01, Vol.32 (6), p.522-532
Hauptverfasser:	Li, Min, Khan, Altaf-M., Maderdrut, Jerome L., Simon, Eric E., Batuman, Vecihi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - pathology Acute Kidney Injury - physiopathology Adaptor Proteins, Vesicular Transport - metabolism Animals Apoptosis - drug effects Chemokine CCL2 - metabolism Cumulus Cells Epithelial Cells - pathology Hypoxia Immunity, Innate Interferon Regulatory Factor-3 - metabolism Interleukin-6 - metabolism Kidney Tubules, Proximal - pathology Mice Myeloid Differentiation Factor 88 - metabolism Myeloid Differentiation Factor 88 - physiology Original Report: Laboratory Investigation Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology Pituitary Adenylate Cyclase-Activating Polypeptide - physiology Reperfusion Injury - pathology Reperfusion Injury - physiopathology Signal Transduction - drug effects TNF Receptor-Associated Factor 6 - metabolism Toll-Like Receptor 4 - metabolism Toll-Like Receptor 4 - physiology
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