Factors influencing the mechanical behaviour of healthy human descending thoracic aorta
In recent times, significant effort has been made to understand the mechanical behaviour of the arterial wall and how it is affected by the different vascular pathologies. However, to be able to interpret the results correctly, it is essential that the influence of other factors, such as aging or an...
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| Veröffentlicht in: | Physiological measurement 2010-12, Vol.31 (12), p.1553-1565 |
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| creator | Guinea, Gustavo V Atienza, José M Rojo, Francisco J García-Herrera, Claudio M Yiqun, Li Claes, Els Goicolea, José M García-Montero, Carlos Burgos, Raúl L Goicolea, Francisco J Elices, Manuel |
| description | In recent times, significant effort has been made to understand the mechanical behaviour of the arterial wall and how it is affected by the different vascular pathologies. However, to be able to interpret the results correctly, it is essential that the influence of other factors, such as aging or anisotropy, be understood. Knowledge of mechanical behaviour of the aorta has been customarily constrained by lack of data on fresh aortic tissue, especially from healthy young individuals. In addition, information regarding the point of rupture is also very limited. In this study, the mechanical behaviour of the descending thoracic aorta of 28 organ donors with no apparent disease, whose ages vary from 17 to 60 years, is evaluated. Tensile tests up to rupture are carried out to evaluate the influence of age and wall anisotropy. Results reveal that the tensile strength and stretch at failure of healthy descending aortas show a significant reduction with age, falling abruptly beyond the age of 30. This fact places age as a key factor when mechanical properties of descending aorta are considered. |
| doi_str_mv | 10.1088/0967-3334/31/12/001 |
| format | Article |
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| source | MEDLINE; IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | Adolescent Adult Aorta, Thoracic - physiology Biomechanical Phenomena - physiology Elbow - physiology Female Health Humans Male Middle Aged Risk Factors Tensile Strength - physiology Young Adult |
| title | Factors influencing the mechanical behaviour of healthy human descending thoracic aorta |
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