Retinoid modulation of phorbol ester effects in skin
This chapter reviews convenient assay methods for retinoids against phorbol ester-induced effects in the skin. The chapter describes methods for measuring 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced edema, ornithine decarboxylase (ODC) activity, and DNA synthesis. Measurements of TPA-induced...
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| Veröffentlicht in: | Methods in Enzymology 1990, Vol.190, p.346-352 |
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| creator | Gendimenico, Gerard J. Capetola, Robert J. Rosenthale, Marvin E. McGuire, John L. Mezick, James A. |
| description | This chapter reviews convenient assay methods for retinoids against phorbol ester-induced effects in the skin. The chapter describes methods for measuring 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced edema, ornithine decarboxylase (ODC) activity, and DNA synthesis. Measurements of TPA-induced ear edema, ODC activity, and DNA synthesis provide convenient methods to assess the effects of retinoids on phorbol ester-mediated events in the skin. The antiinflammatory effects of retinoids in the TPA ear edema model may be due to their action as inhibitors of arachidonic acid metabolism, all-trans-Retinoic acid and 13-cis-retinoic acid are reported to act as inhibitors of snake venom phospholipase A2 and to inhibit the release and metabolism of arachidonic acid in calcium ionophore-stimulated rat peritoneal macrophages. In TPAtreated mouse skin, phospholipase A2 activity is elevated and would provide a source of free arachidonic acid for metabolism into prostaglandin E2 (PGE2)and 15-hydroxyeicosatetraenoic acids (HETE). |
| doi_str_mv | 10.1016/0076-6879(90)90040-8 |
| format | Article |
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The chapter describes methods for measuring 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced edema, ornithine decarboxylase (ODC) activity, and DNA synthesis. Measurements of TPA-induced ear edema, ODC activity, and DNA synthesis provide convenient methods to assess the effects of retinoids on phorbol ester-mediated events in the skin. The antiinflammatory effects of retinoids in the TPA ear edema model may be due to their action as inhibitors of arachidonic acid metabolism, all-trans-Retinoic acid and 13-cis-retinoic acid are reported to act as inhibitors of snake venom phospholipase A2 and to inhibit the release and metabolism of arachidonic acid in calcium ionophore-stimulated rat peritoneal macrophages. In TPAtreated mouse skin, phospholipase A2 activity is elevated and would provide a source of free arachidonic acid for metabolism into prostaglandin E2 (PGE2)and 15-hydroxyeicosatetraenoic acids (HETE).</description><identifier>ISSN: 0076-6879</identifier><identifier>ISBN: 0121820912</identifier><identifier>ISBN: 9780121820916</identifier><identifier>EISSN: 1557-7988</identifier><identifier>DOI: 10.1016/0076-6879(90)90040-8</identifier><identifier>PMID: 2087187</identifier><identifier>CODEN: MENZAU</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Science & Technology</publisher><subject>Animals ; Biological and medical sciences ; Edema - chemically induced ; Edema - prevention & control ; Female ; Male ; Medical sciences ; Mice ; Mice, Inbred Strains ; Ornithine Decarboxylase - metabolism ; Pharmacology. Drug treatments ; Reference Values ; Skin - drug effects ; Skin - enzymology ; Skin - pathology ; Skin, nail, hair, dermoskeleton ; Stereoisomerism ; Tetradecanoylphorbol Acetate - toxicity ; Tretinoin - pharmacology</subject><ispartof>Methods in Enzymology, 1990, Vol.190, p.346-352</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-22a9a0523a8c3460558c37a311e5b69661f9ded873e413317412440192729e803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0076687990900408$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,779,780,784,793,3459,3550,4024,11288,27923,27924,27925,45810,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19538239$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2087187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gendimenico, Gerard J.</creatorcontrib><creatorcontrib>Capetola, Robert J.</creatorcontrib><creatorcontrib>Rosenthale, Marvin E.</creatorcontrib><creatorcontrib>McGuire, John L.</creatorcontrib><creatorcontrib>Mezick, James A.</creatorcontrib><title>Retinoid modulation of phorbol ester effects in skin</title><title>Methods in Enzymology</title><addtitle>Methods Enzymol</addtitle><description>This chapter reviews convenient assay methods for retinoids against phorbol ester-induced effects in the skin. The chapter describes methods for measuring 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced edema, ornithine decarboxylase (ODC) activity, and DNA synthesis. Measurements of TPA-induced ear edema, ODC activity, and DNA synthesis provide convenient methods to assess the effects of retinoids on phorbol ester-mediated events in the skin. The antiinflammatory effects of retinoids in the TPA ear edema model may be due to their action as inhibitors of arachidonic acid metabolism, all-trans-Retinoic acid and 13-cis-retinoic acid are reported to act as inhibitors of snake venom phospholipase A2 and to inhibit the release and metabolism of arachidonic acid in calcium ionophore-stimulated rat peritoneal macrophages. In TPAtreated mouse skin, phospholipase A2 activity is elevated and would provide a source of free arachidonic acid for metabolism into prostaglandin E2 (PGE2)and 15-hydroxyeicosatetraenoic acids (HETE).</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Edema - chemically induced</subject><subject>Edema - prevention & control</subject><subject>Female</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Ornithine Decarboxylase - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Values</subject><subject>Skin - drug effects</subject><subject>Skin - enzymology</subject><subject>Skin - pathology</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Stereoisomerism</subject><subject>Tetradecanoylphorbol Acetate - toxicity</subject><subject>Tretinoin - pharmacology</subject><issn>0076-6879</issn><issn>1557-7988</issn><isbn>0121820912</isbn><isbn>9780121820916</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtLw0AQhRcv1Fr7DxTyIuhDdGY3e3sRpHiDgiD6vGyTCa6mSdlNBf-9qS2dlwNzPoYzh7FzhBsEVLcAWuXKaHtl4doCFJCbAzZGKXWurTGH7BSQo-FgkR-x8Z4_YdOUvmAYqZQAMWIjDkaj0WNWvFEf2i5U2bKr1o3vQ9dmXZ2tPru46JqMUk8xo7qmsk9ZaLP0Hdozdlz7JtF0pxP28fjwPnvO569PL7P7eV6Kgvc55956kFx4MywUSDmo9gKR5EJZpbC2FVVGCypQCNQF8qIAtFxzSwbEhF1s767WiyVVbhXD0sdft0s_-Jc736fSN3X0bRnSHkMrheHCDtzdlqMh7E-g6FIZqC2pCnH4y1VdcAhu07LbtOY2rTkL7r9lZ8QfWBhoLA</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Gendimenico, Gerard J.</creator><creator>Capetola, Robert J.</creator><creator>Rosenthale, Marvin E.</creator><creator>McGuire, John L.</creator><creator>Mezick, James A.</creator><general>Elsevier Science & Technology</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>1990</creationdate><title>Retinoid modulation of phorbol ester effects in skin</title><author>Gendimenico, Gerard J. ; Capetola, Robert J. ; Rosenthale, Marvin E. ; McGuire, John L. ; Mezick, James A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-22a9a0523a8c3460558c37a311e5b69661f9ded873e413317412440192729e803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Edema - chemically induced</topic><topic>Edema - prevention & control</topic><topic>Female</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Ornithine Decarboxylase - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Reference Values</topic><topic>Skin - drug effects</topic><topic>Skin - enzymology</topic><topic>Skin - pathology</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Stereoisomerism</topic><topic>Tetradecanoylphorbol Acetate - toxicity</topic><topic>Tretinoin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gendimenico, Gerard J.</creatorcontrib><creatorcontrib>Capetola, Robert J.</creatorcontrib><creatorcontrib>Rosenthale, Marvin E.</creatorcontrib><creatorcontrib>McGuire, John L.</creatorcontrib><creatorcontrib>Mezick, James A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Methods in Enzymology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gendimenico, Gerard J.</au><au>Capetola, Robert J.</au><au>Rosenthale, Marvin E.</au><au>McGuire, John L.</au><au>Mezick, James A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoid modulation of phorbol ester effects in skin</atitle><jtitle>Methods in Enzymology</jtitle><addtitle>Methods Enzymol</addtitle><date>1990</date><risdate>1990</risdate><volume>190</volume><spage>346</spage><epage>352</epage><pages>346-352</pages><issn>0076-6879</issn><eissn>1557-7988</eissn><isbn>0121820912</isbn><isbn>9780121820916</isbn><coden>MENZAU</coden><abstract>This chapter reviews convenient assay methods for retinoids against phorbol ester-induced effects in the skin. The chapter describes methods for measuring 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced edema, ornithine decarboxylase (ODC) activity, and DNA synthesis. Measurements of TPA-induced ear edema, ODC activity, and DNA synthesis provide convenient methods to assess the effects of retinoids on phorbol ester-mediated events in the skin. The antiinflammatory effects of retinoids in the TPA ear edema model may be due to their action as inhibitors of arachidonic acid metabolism, all-trans-Retinoic acid and 13-cis-retinoic acid are reported to act as inhibitors of snake venom phospholipase A2 and to inhibit the release and metabolism of arachidonic acid in calcium ionophore-stimulated rat peritoneal macrophages. In TPAtreated mouse skin, phospholipase A2 activity is elevated and would provide a source of free arachidonic acid for metabolism into prostaglandin E2 (PGE2)and 15-hydroxyeicosatetraenoic acids (HETE).</abstract><cop>San Diego, CA</cop><pub>Elsevier Science & Technology</pub><pmid>2087187</pmid><doi>10.1016/0076-6879(90)90040-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Methods in Enzymology, 1990, Vol.190, p.346-352 |
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| subjects | Animals Biological and medical sciences Edema - chemically induced Edema - prevention & control Female Male Medical sciences Mice Mice, Inbred Strains Ornithine Decarboxylase - metabolism Pharmacology. Drug treatments Reference Values Skin - drug effects Skin - enzymology Skin - pathology Skin, nail, hair, dermoskeleton Stereoisomerism Tetradecanoylphorbol Acetate - toxicity Tretinoin - pharmacology |
| title | Retinoid modulation of phorbol ester effects in skin |
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