Administration of rat acute-phase protein α(2)-macroglobulin before total-body irradiation initiates cytoprotective mechanisms in the liver

Previously, we showed that administration of the acute-phase protein α(2)-macroglobulin (α(2)M) to rats before total-body irradiation with 6.7 Gy (LD(50/30)) of X-rays provides the same level of radioprotection as amifostine. Here, we compare the cytoprotective effects of α(2)M and amifostine on rat...

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Veröffentlicht in:	Radiation and environmental biophysics 2011-03, Vol.50 (1), p.167
Hauptverfasser:	Bogojević, Desanka, Poznanović, Goran, Grdović, Nevena, Grigorov, Ilijana, Vidaković, Melita, Dinić, Svetlana, Mihailović, Mirjana
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Macroglobulins - administration & dosage alpha-Macroglobulins - pharmacology Amifostine - pharmacology Animals Antioxidants - metabolism Catalase - metabolism Cell Proliferation - drug effects Cell Proliferation - radiation effects Cytoprotection - drug effects DNA Repair - drug effects DNA Repair - radiation effects Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - radiation effects Interleukin-6 - blood Liver - cytology Liver - drug effects Liver - metabolism Liver - radiation effects Radiation Dosage Rats Rats, Wistar Reactive Oxygen Species - metabolism Superoxide Dismutase - metabolism Transcription Factor RelA - metabolism Whole-Body Irradiation
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