D1 and D2 dopamine receptors in separate circuits cooperate to drive associative long-term potentiation in the prefrontal cortex

Dopamine release associated with motivational arousal is thought to drive goal-directed learning and consolidation of acquired memories. This dopamine hypothesis of learning and motivation directly suggests that dopamine is necessary for modifications of excitatory synapses in dopamine terminal fiel...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-09, Vol.107 (37), p.16366-16371
Hauptverfasser:	Xu, Tai-Xiang, Yao, Wei-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arousal Biological Sciences Brain Channel gating Circuits Cortex (prefrontal) Dopamine Dopamine D1 receptors Dopamine D2 receptors gamma -Aminobutyric acid gamma-Aminobutyric Acid - metabolism Interneurons Ion Channel Gating Learning Long term potentiation Memory Mice Mice, Inbred C57BL Motivation Neurons Neuroscience Neurotransmission Plasticity Plasticity (synaptic) Prefrontal cortex Prefrontal Cortex - metabolism Pyramidal cells Receptors Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Synapses Synaptic Transmission
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