Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice

A hallmark of Alzheimer disease (AD) is the deposition of amyloid β (Aβ) in brain parenchyma and cerebral blood vessels, accompanied by cognitive decline. Previously, we showed that human apolipoprotein A-I (apoA-I) decreases Aβ(40) aggregation and toxicity. Here we demonstrate that apoA-I in lipida...

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Veröffentlicht in:	The Journal of biological chemistry 2010-11, Vol.285 (47), p.36945
Hauptverfasser:	Lefterov, Iliya, Fitz, Nicholas F, Cronican, Andrea A, Fogg, Allison, Lefterov, Preslav, Kodali, Ravindra, Wetzel, Ronald, Koldamova, Radosveta
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - physiology Animals Apolipoprotein A-I - physiology Behavior, Animal Blotting, Western Brain - metabolism Brain - pathology Cells, Cultured Cerebral Amyloid Angiopathy - etiology Cerebral Amyloid Angiopathy - pathology Cholesterol - metabolism Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Enzyme-Linked Immunosorbent Assay Humans Immunoenzyme Techniques Maze Learning Memory Disorders - etiology Memory Disorders - pathology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mutation - genetics Myocytes, Smooth Muscle - metabolism Presenilin-1 - physiology Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sequence Deletion
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