Roles for the transcription elongation factor NusA in both DNA repair and damage tolerance pathways in Escherichia coli

We report observations suggesting that the transcription elongation factor NusA promotes a previously unrecognized class of transcription-coupled repair (TCR) in addition to its previously proposed role in recruiting translesion synthesis (TLS) DNA polymerases to gaps encountered during transcriptio...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-08, Vol.107 (35), p.15517-15522
Hauptverfasser:	Cohen, Susan E., Lewis, Cindi A., Mooney, Rachel A., Kohanski, Michael A., Collins, James J., Landick, Robert, Walker, Graham C., Roberts, Jeffrey W.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Nitroquinoline-1-oxide - pharmacology Anti-Infective Agents - pharmacology Biological Sciences Blotting, Far-Western Cell lines DNA DNA biosynthesis DNA Damage DNA polymerase DNA Repair DNA-directed DNA polymerase DNA-directed RNA polymerase DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Dose-Response Relationship, Drug Drug Resistance, Bacterial E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli - physiology Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Escherichia coli Proteins - physiology Gene expression Gene Expression Profiling Gene Expression Regulation, Bacterial - drug effects Genes Genetic analysis Genetic mutation Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Lesions Microbial Viability - drug effects Microscopy, Fluorescence Mutation Nitrofurazone - pharmacology Nucleotide excision repair Peptide elongation factors Peptide Elongation Factors - genetics Peptide Elongation Factors - metabolism Peptide Elongation Factors - physiology Quinolones - pharmacology Rec A Recombinases - genetics Rec A Recombinases - metabolism RNA Signal Transduction - drug effects Signal Transduction - physiology Temperature Temperature effects Transcription elongation Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Transcription, Genetic - drug effects transcription-coupled repair Transcriptional Elongation Factors U.V. radiation
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