Efficacy of Aztreonam in the Treatment of Skeletal Infections Due to Pseudomonas aeruginosa
Twenty-eight patients with skeletal infections due to Pseudomonas aeruginosa were treated with aztreonam during two open, noncomparative, multicenter clinical trials. Ten patients with septic arthritis received 2 g of aztreonam three times a day (modal) for 30 days (mean). The mean follow-up period...
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| Veröffentlicht in: | Reviews of infectious diseases 1991-05, Vol.13, p.S634-S639 |
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| creator | Conrad, Dennis A. R. Rex Williams Terry L. Couchman Arnold L. Lentnek |
| description | Twenty-eight patients with skeletal infections due to Pseudomonas aeruginosa were treated with aztreonam during two open, noncomparative, multicenter clinical trials. Ten patients with septic arthritis received 2 g of aztreonam three times a day (modal) for 30 days (mean). The mean follow-up period was 4 weeks. Microbiologic cure was achieved in all 10 patients; complete clinical cure, in eight; and partial clinical cure, in two. Eighteen cases of osteomyelitis were treated with 2 g of aztreonam three times a day (modal) for 40 days (mean), with a mean follow-up period of 6 months. Microbiologic cure was achieved in 17 patients. Relapse occurred 1 month after therapy in one patient. Complete clinical cure was achieved in 13 and partial clinical cure was achieved in five patients. The most common adverse reactions to aztreonam were a transient elevation in levels of hepatic enzymes and transient eosinophilia. Three superinfections and one subsequent infection occurred. These results support use of aztreonam for the treatment of skeletal infections due to P. aeruginosa. |
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Rex Williams ; Terry L. Couchman ; Arnold L. Lentnek</creator><creatorcontrib>Conrad, Dennis A. ; R. Rex Williams ; Terry L. Couchman ; Arnold L. Lentnek</creatorcontrib><description>Twenty-eight patients with skeletal infections due to Pseudomonas aeruginosa were treated with aztreonam during two open, noncomparative, multicenter clinical trials. Ten patients with septic arthritis received 2 g of aztreonam three times a day (modal) for 30 days (mean). The mean follow-up period was 4 weeks. Microbiologic cure was achieved in all 10 patients; complete clinical cure, in eight; and partial clinical cure, in two. Eighteen cases of osteomyelitis were treated with 2 g of aztreonam three times a day (modal) for 40 days (mean), with a mean follow-up period of 6 months. Microbiologic cure was achieved in 17 patients. Relapse occurred 1 month after therapy in one patient. Complete clinical cure was achieved in 13 and partial clinical cure was achieved in five patients. The most common adverse reactions to aztreonam were a transient elevation in levels of hepatic enzymes and transient eosinophilia. Three superinfections and one subsequent infection occurred. These results support use of aztreonam for the treatment of skeletal infections due to P. aeruginosa.</description><identifier>ISSN: 0162-0886</identifier><identifier>PMID: 2068473</identifier><language>eng</language><publisher>United States: University of Chicago Press</publisher><subject>Adolescent ; Adult ; Aged ; Arthritis ; Arthritis, Infectious - complications ; Arthritis, Infectious - drug therapy ; Aztreonam - adverse effects ; Aztreonam - therapeutic use ; Bones ; Child ; Clinical trials ; Dosage ; Female ; Humans ; Infections ; Male ; Medical cures ; Middle Aged ; Miscellaneous Infections ; Osteomyelitis ; Osteomyelitis - complications ; Osteomyelitis - drug therapy ; Pathogens ; Prospective Studies ; Pseudomonas Infections - complications ; Pseudomonas Infections - drug therapy ; Relapse ; Superinfection - etiology ; Symptoms</subject><ispartof>Reviews of infectious diseases, 1991-05, Vol.13, p.S634-S639</ispartof><rights>Copyright 1991 The University of Chicago</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4456013$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4456013$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2068473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conrad, Dennis A.</creatorcontrib><creatorcontrib>R. Rex Williams</creatorcontrib><creatorcontrib>Terry L. Couchman</creatorcontrib><creatorcontrib>Arnold L. Lentnek</creatorcontrib><title>Efficacy of Aztreonam in the Treatment of Skeletal Infections Due to Pseudomonas aeruginosa</title><title>Reviews of infectious diseases</title><addtitle>Rev Infect Dis</addtitle><description>Twenty-eight patients with skeletal infections due to Pseudomonas aeruginosa were treated with aztreonam during two open, noncomparative, multicenter clinical trials. Ten patients with septic arthritis received 2 g of aztreonam three times a day (modal) for 30 days (mean). The mean follow-up period was 4 weeks. Microbiologic cure was achieved in all 10 patients; complete clinical cure, in eight; and partial clinical cure, in two. Eighteen cases of osteomyelitis were treated with 2 g of aztreonam three times a day (modal) for 40 days (mean), with a mean follow-up period of 6 months. Microbiologic cure was achieved in 17 patients. Relapse occurred 1 month after therapy in one patient. Complete clinical cure was achieved in 13 and partial clinical cure was achieved in five patients. The most common adverse reactions to aztreonam were a transient elevation in levels of hepatic enzymes and transient eosinophilia. Three superinfections and one subsequent infection occurred. These results support use of aztreonam for the treatment of skeletal infections due to P. aeruginosa.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Arthritis</subject><subject>Arthritis, Infectious - complications</subject><subject>Arthritis, Infectious - drug therapy</subject><subject>Aztreonam - adverse effects</subject><subject>Aztreonam - therapeutic use</subject><subject>Bones</subject><subject>Child</subject><subject>Clinical trials</subject><subject>Dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Medical cures</subject><subject>Middle Aged</subject><subject>Miscellaneous Infections</subject><subject>Osteomyelitis</subject><subject>Osteomyelitis - complications</subject><subject>Osteomyelitis - drug therapy</subject><subject>Pathogens</subject><subject>Prospective Studies</subject><subject>Pseudomonas Infections - complications</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Relapse</subject><subject>Superinfection - etiology</subject><subject>Symptoms</subject><issn>0162-0886</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j8tOwzAURL0AlVL4A5D8A5H8ip0sq1KgUiWQKCsWlWPfCwlJXMXOonw9Qa1YzeJoZnQuyJxxLTJWFPqKXMfYMJZLo_SMzATThTJyTj7WiLWz7kgD0uVPGiD0tqN1T9MX0N0ANnXQpz_69g0tJNvSTY_gUh36SB9GoCnQ1wijD91UjdTCMH7WfYj2hlyibSPcnnNB3h_Xu9Vztn152qyW26wRwqRM-IohVkqWJSpu0HvjnZguqtLb0tgiL9BwLRlngLxUkwEKljMH1jrNUS7I_Wn3MFYd-P1hqDs7HPdnyYnfnXgTUxj-sVK5ZlzKXyPFV7I</recordid><startdate>19910501</startdate><enddate>19910501</enddate><creator>Conrad, Dennis A.</creator><creator>R. Rex Williams</creator><creator>Terry L. Couchman</creator><creator>Arnold L. Lentnek</creator><general>University of Chicago Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19910501</creationdate><title>Efficacy of Aztreonam in the Treatment of Skeletal Infections Due to Pseudomonas aeruginosa</title><author>Conrad, Dennis A. ; R. Rex Williams ; Terry L. Couchman ; Arnold L. Lentnek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j227t-2db0ffb4399f417fdd7dc2fecb9da97a858f7163010ef194746f2050ceaac61f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Arthritis</topic><topic>Arthritis, Infectious - complications</topic><topic>Arthritis, Infectious - drug therapy</topic><topic>Aztreonam - adverse effects</topic><topic>Aztreonam - therapeutic use</topic><topic>Bones</topic><topic>Child</topic><topic>Clinical trials</topic><topic>Dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Medical cures</topic><topic>Middle Aged</topic><topic>Miscellaneous Infections</topic><topic>Osteomyelitis</topic><topic>Osteomyelitis - complications</topic><topic>Osteomyelitis - drug therapy</topic><topic>Pathogens</topic><topic>Prospective Studies</topic><topic>Pseudomonas Infections - complications</topic><topic>Pseudomonas Infections - drug therapy</topic><topic>Relapse</topic><topic>Superinfection - etiology</topic><topic>Symptoms</topic><toplevel>online_resources</toplevel><creatorcontrib>Conrad, Dennis A.</creatorcontrib><creatorcontrib>R. Rex Williams</creatorcontrib><creatorcontrib>Terry L. Couchman</creatorcontrib><creatorcontrib>Arnold L. Lentnek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Reviews of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conrad, Dennis A.</au><au>R. Rex Williams</au><au>Terry L. Couchman</au><au>Arnold L. Lentnek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Aztreonam in the Treatment of Skeletal Infections Due to Pseudomonas aeruginosa</atitle><jtitle>Reviews of infectious diseases</jtitle><addtitle>Rev Infect Dis</addtitle><date>1991-05-01</date><risdate>1991</risdate><volume>13</volume><spage>S634</spage><epage>S639</epage><pages>S634-S639</pages><issn>0162-0886</issn><abstract>Twenty-eight patients with skeletal infections due to Pseudomonas aeruginosa were treated with aztreonam during two open, noncomparative, multicenter clinical trials. Ten patients with septic arthritis received 2 g of aztreonam three times a day (modal) for 30 days (mean). The mean follow-up period was 4 weeks. Microbiologic cure was achieved in all 10 patients; complete clinical cure, in eight; and partial clinical cure, in two. Eighteen cases of osteomyelitis were treated with 2 g of aztreonam three times a day (modal) for 40 days (mean), with a mean follow-up period of 6 months. Microbiologic cure was achieved in 17 patients. Relapse occurred 1 month after therapy in one patient. Complete clinical cure was achieved in 13 and partial clinical cure was achieved in five patients. The most common adverse reactions to aztreonam were a transient elevation in levels of hepatic enzymes and transient eosinophilia. Three superinfections and one subsequent infection occurred. These results support use of aztreonam for the treatment of skeletal infections due to P. aeruginosa.</abstract><cop>United States</cop><pub>University of Chicago Press</pub><pmid>2068473</pmid></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adolescent Adult Aged Arthritis Arthritis, Infectious - complications Arthritis, Infectious - drug therapy Aztreonam - adverse effects Aztreonam - therapeutic use Bones Child Clinical trials Dosage Female Humans Infections Male Medical cures Middle Aged Miscellaneous Infections Osteomyelitis Osteomyelitis - complications Osteomyelitis - drug therapy Pathogens Prospective Studies Pseudomonas Infections - complications Pseudomonas Infections - drug therapy Relapse Superinfection - etiology Symptoms |
| title | Efficacy of Aztreonam in the Treatment of Skeletal Infections Due to Pseudomonas aeruginosa |
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