Molecular cloning and characterization of the yeast gene for squalene synthetase

Squalene synthetase (farnesyl-diphosphate: farnesyl-diphosphate farnesyltransferase, EC 2.5.1.21) is a critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway. The structural gene for this enzyme was cloned fro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-07, Vol.88 (14), p.6038-6042
Hauptverfasser:	Jennings, S.M. (Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ), Tsay, Y.H, Fisch, T.M, Robinson, G.W
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Amino Acid Sequence Amino acids Base Sequence Biological and medical sciences CHOLESTEROL CLONACION CLONAGE Cloning, Molecular - methods COLESTEROL deletion mutant Diploidy DNA Enzymes ESCHERICHIA Escherichia coli - genetics EXPRESION GENICA EXPRESSION DES GENES farensyl-diphosphate farensyltransferase Farnesyl-Diphosphate Farnesyltransferase - genetics Farnesyl-Diphosphate Farnesyltransferase - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Gene Library Genes Genes, Fungal Genes. Genome Genetic Complementation Test GENETICA GENETICA MOLECULAR GENETIQUE GENETIQUE MOLECULAIRE GENOTIPOS GENOTYPE LIASAS LYASE Microsomes - enzymology Molecular and cellular biology Molecular genetics Molecular Sequence Data Molecular Weight MUTACION MUTATION Nucleic Acid Hybridization NUCLEOTIDE nucleotide sequence NUCLEOTIDOS Pests PLASMIDE PLASMIDIOS Plasmids Protein Conformation Proteins Recombinant Proteins - metabolism Restriction Mapping SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Sequence Homology, Nucleic Acid Squalene TRITERPENOIDE TRITERPENOIDOS Yeasts
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