Activation of alpha4 nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption

Recently, the smoking cessation therapeutic varenicline, a nicotinic acetylcholine receptor (nAChR) partial agonist, has been shown to reduce alcohol consumption. However, the mechanism and nAChR subtype(s) involved are unknown. Here we demonstrate that varenicline and alcohol exposure, either alone...

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Veröffentlicht in:	The Journal of neuroscience 2010-07, Vol.30 (30), p.10169
Hauptverfasser:	Hendrickson, Linzy M, Zhao-Shea, Rubing, Pang, Xueyan, Gardner, Paul D, Tapper, Andrew R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - genetics Alcohol Drinking - drug therapy Alcohol Drinking - genetics Alcohol Drinking - pathology Analysis of Variance Animals Benzazepines - therapeutic use Central Nervous System Depressants - administration & dosage Disease Models, Animal Dopamine - metabolism Dose-Response Relationship, Drug Drinking Behavior - drug effects Drinking Behavior - physiology Drug Combinations Ethanol - administration & dosage Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Leucine - genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Mutation - genetics Neurons - drug effects Neurons - metabolism Nicotinic Agonists - therapeutic use Proto-Oncogene Proteins c-fos - metabolism Quinoxalines - therapeutic use Receptors, Nicotinic - deficiency Receptors, Nicotinic - metabolism Tyrosine 3-Monooxygenase - metabolism Varenicline Ventral Tegmental Area - cytology Ventral Tegmental Area - drug effects
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