ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma

Historically, ErbB3 has been overlooked within the ErbB receptor family due to its perceived lack of tyrosine kinase activity. We have previously demonstrated that in pancreatic cancer ErbB3 is the preferred dimerization partner of EGFR, ErbB3 protein expression level directly correlates with the an...

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Veröffentlicht in:	Cancer biology & therapy 2010-09, Vol.10 (6), p.555-563
Hauptverfasser:	Liles, J. Spencer, Arnoletti, J. Pablo, Tzeng, Ching-Wei D., Howard, J. Harrison, Kossenkov, Andrew V., Kulesza, Peter, Heslin, Martin J., Frolov, Andrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Binding Biology Bioscience Blotting, Western Calcium Cancer Cell Cell Line, Tumor Cell Proliferation - drug effects Chromones - pharmacology Cycle Dose-Response Relationship, Drug ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Erlotinib Hydrochloride Female Flavonoids - pharmacology Gene Expression Regulation, Neoplastic Humans Landes Mice Mice, SCID Morpholines - pharmacology Organogenesis Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phosphatidylinositol 3-Kinases - metabolism Protein Kinase Inhibitors - pharmacology Proteins Proto-Oncogene Proteins c-akt - metabolism Quinazolines - pharmacology Receptor, ErbB-3 - genetics Receptor, ErbB-3 - metabolism Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction - drug effects Tumor Burden - drug effects Xenograft Model Antitumor Assays
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