Identification of Novel Mutations Responsible for Resistance to MK-2048, a Second-Generation HIV-1 Integrase Inhibitor
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| Veröffentlicht in: | Journal of Virology 2010-09, Vol.84 (18), p.9210-9216 |
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| container_title | Journal of Virology |
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| creator | Bar-Magen, Tamara Sloan, Richard D Donahue, Daniel A Kuhl, Björn D Zabeida, Alexandra Xu, Hongtao Oliveira, Maureen Hazuda, Daria J Wainberg, Mark A |
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| doi_str_mv | 10.1128/JVI.01164-10 |
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</description><identifier>ISSN: 0022-538X</identifier><identifier>EISSN: 1098-5514</identifier><identifier>DOI: 10.1128/JVI.01164-10</identifier><identifier>PMID: 20610719</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Amino Acid Substitution - genetics ; DNA Mutational Analysis ; Drug Resistance, Viral ; HIV Integrase - chemistry ; HIV Integrase - genetics ; HIV Integrase - metabolism ; HIV Integrase Inhibitors - pharmacology ; HIV-1 - drug effects ; HIV-1 - genetics ; HIV-1 - physiology ; Human immunodeficiency virus 1 ; Humans ; Models, Molecular ; Molecular Structure ; Mutagenesis, Site-Directed ; Mutation, Missense ; Protein Structure, Tertiary ; Pyrrolidinones - pharmacology ; Quinolones - pharmacology ; Raltegravir Potassium ; RNA, Viral - genetics ; Vaccines and Antiviral Agents ; Virus Replication - drug effects</subject><ispartof>Journal of Virology, 2010-09, Vol.84 (18), p.9210-9216</ispartof><rights>Copyright © 2010, American Society for Microbiology 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-ef2dbe57ce4d699ad17c0a69af18f16b474847acab635aac2fd97ea4c629fa953</citedby><cites>FETCH-LOGICAL-c508t-ef2dbe57ce4d699ad17c0a69af18f16b474847acab635aac2fd97ea4c629fa953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937597/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937597/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20610719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bar-Magen, Tamara</creatorcontrib><creatorcontrib>Sloan, Richard D</creatorcontrib><creatorcontrib>Donahue, Daniel A</creatorcontrib><creatorcontrib>Kuhl, Björn D</creatorcontrib><creatorcontrib>Zabeida, Alexandra</creatorcontrib><creatorcontrib>Xu, Hongtao</creatorcontrib><creatorcontrib>Oliveira, Maureen</creatorcontrib><creatorcontrib>Hazuda, Daria J</creatorcontrib><creatorcontrib>Wainberg, Mark A</creatorcontrib><title>Identification of Novel Mutations Responsible for Resistance to MK-2048, a Second-Generation HIV-1 Integrase Inhibitor</title><title>Journal of Virology</title><addtitle>J Virol</addtitle><description>Article Usage Stats
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</description><subject>Amino Acid Substitution - genetics</subject><subject>DNA Mutational Analysis</subject><subject>Drug Resistance, Viral</subject><subject>HIV Integrase - chemistry</subject><subject>HIV Integrase - genetics</subject><subject>HIV Integrase - metabolism</subject><subject>HIV Integrase Inhibitors - pharmacology</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Mutagenesis, Site-Directed</subject><subject>Mutation, Missense</subject><subject>Protein Structure, Tertiary</subject><subject>Pyrrolidinones - pharmacology</subject><subject>Quinolones - pharmacology</subject><subject>Raltegravir Potassium</subject><subject>RNA, Viral - genetics</subject><subject>Vaccines and Antiviral Agents</subject><subject>Virus Replication - drug effects</subject><issn>0022-538X</issn><issn>1098-5514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9vFCEUx4nR2G315tkQL146FRhmgIuJaWw72mrij8YbecM8dmlmhxVm1_jfS7u10dODxyefB3wJecHZCedCv_lw3Z0wzltZcfaILDgzumoaLh-TBWNCVE2tfxyQw5xvGONStvIpORCs5UxxsyC7bsBpDj44mEOcaPT0U9zhSK-2810n0y-YN6WGfkTqY7rdhzzD5JDOkV59rAST-pgC_YouTkN1jhOmve2iu6447aYZlwkyltUq9GGO6Rl54mHM-Py-HpHvZ--_nV5Ul5_Pu9N3l5VrmJ4r9GLosVEO5dAaAwNXjkFrwHPtedtLJbVU4KBv6wbACT8YhSBdK4wH09RH5O3eu9n2axxceWuC0W5SWEP6bSME-__JFFZ2GXdWmFo1RhXB63tBij-3mGe7DtnhOMKEcZutKl9dC6XrQh7vSZdizgn9wxTO7G1StiRl75IqnYK__PdmD_DfaArwag-swnL1KyS0kNf2ZhesLgJtjSiWPx9ym-g</recordid><startdate>20100915</startdate><enddate>20100915</enddate><creator>Bar-Magen, Tamara</creator><creator>Sloan, Richard D</creator><creator>Donahue, Daniel A</creator><creator>Kuhl, Björn D</creator><creator>Zabeida, Alexandra</creator><creator>Xu, Hongtao</creator><creator>Oliveira, Maureen</creator><creator>Hazuda, Daria J</creator><creator>Wainberg, Mark A</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20100915</creationdate><title>Identification of Novel Mutations Responsible for Resistance to MK-2048, a Second-Generation HIV-1 Integrase Inhibitor</title><author>Bar-Magen, Tamara ; 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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>20610719</pmid><doi>10.1128/JVI.01164-10</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-538X |
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| issn | 0022-538X 1098-5514 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino Acid Substitution - genetics DNA Mutational Analysis Drug Resistance, Viral HIV Integrase - chemistry HIV Integrase - genetics HIV Integrase - metabolism HIV Integrase Inhibitors - pharmacology HIV-1 - drug effects HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus 1 Humans Models, Molecular Molecular Structure Mutagenesis, Site-Directed Mutation, Missense Protein Structure, Tertiary Pyrrolidinones - pharmacology Quinolones - pharmacology Raltegravir Potassium RNA, Viral - genetics Vaccines and Antiviral Agents Virus Replication - drug effects |
| title | Identification of Novel Mutations Responsible for Resistance to MK-2048, a Second-Generation HIV-1 Integrase Inhibitor |
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