Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway

Protein kinase Cepsilon (PKCepsilon), a diacyglycerol- and phorbol ester-responsive serine-threonine kinase, has been implicated in mitogenic and survival control, and it is markedly overexpressed in human tumors, including in prostate cancer. Although prostate cancer cells undergo apoptosis in resp...

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Veröffentlicht in:	The Journal of biological chemistry 2010-08, Vol.285 (34), p.26033
Hauptverfasser:	Meshki, John, Caino, M Cecilia, von Burstin, Vivian A, Griner, Erin, Kazanietz, Marcelo G
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis bcl-Associated Death Protein Cell Line, Tumor Cell Survival Humans JNK Mitogen-Activated Protein Kinases - metabolism Male Phosphorylation Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein Kinase C-epsilon - metabolism Signal Transduction Tetradecanoylphorbol Acetate - pharmacology Tumor Necrosis Factor-alpha - metabolism
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